Preparation, characterization and cytotoxic activity of new compounds trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]

被引：29

作者：

Ramos-Lima, FJ ^{[1
]}

Quiroga, AG ^{[1
]}

Pérez, JM ^{[1
]}

Navarro-Ranninger, C ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Inorgan, E-28049 Madrid, Spain

来源：

POLYHEDRON | 2003年 / 22卷 / 25-26期

关键词：

trans-platinum complexes; cytotoxic activity; NMR; (hydroxymethyl)-pyridine;

D O I：

10.1016/j.poly.2003.08.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report the synthesis, characterization and cytotoxic assays of new trans-platinum compounds, trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans- [PtCl2NH3(4-(hydroxymethyl)-pyridine)]. In the present work, we found that the replacement of the ammine ligand in "classical" transplatinum with the two new ligands does not increase the cytotoxic activity, maybe because these complexes do not produce a stability of the intrastrand cross-links in DNA. (C) 2003 Published by Elsevier Ltd.

引用

页码：3379 / 3381

页数：3

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