Microwave-assisted silica-supported aluminum chloride-catalyzed Friedel-Crafts alkylation

被引：8
|
作者：
Zupp, Laurine R. [2 ]
Campanella, Veronica L. [2 ]
Rudzinski, DiAndra M. [2 ]
Beland, Francois [3 ]
Priefer, Ronny [1 ,2 ]
机构：
[1] Western New England Univ, Coll Pharm, Springfield, MA 01119 USA
[2] Niagara Univ, Dept Chem Biochem & Phys, New York, NY 14109 USA
[3] SiliCycle Inc, Quebec City, PQ G1P 4S6, Canada
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 39期
关键词：
Friedel-Crafts alkylation; Microwave irradiation; Silica-gel bound aluminum chloride; ONE-POT SYNTHESIS; ARENES;
D O I：
10.1016/j.tetlet.2012.07.131
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Microwave irradiation is a popular method in organic synthesis to achieve high yields in shorter reaction times. This decreases total 'man-hours' in a synthetic setting. Another technique used in organic chemistry to decrease manual manipulations, is solid support reagents. The benefits of this approach is that upon completion of a reaction, a simple filtration can be performed which expedites the work-up and also produces less organic waste. Friedel-Crafts alkylation has been explored using microwave chemistry as well as with solid-supported reagents. In comparison with traditional heating, as well as with AlCl3, superior yields were observed with silica-gel bound aluminum chloride (Si-AlClx) when microwave irradiated for only 5 min. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5343 / 5346
页数：4
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