A NOVEL ELECTRICAL STIMULATION PARADIGM FOR THE SUPPRESSION OF EPILEPTIFORM ACTIVITY IN AN IN VIVO MODEL OF MESIAL TEMPORAL LOBE STATUS EPILEPTICUS

被引：23
|
作者：
Tang, Yuang [1 ]
Durand, Dominique M. [2 ]
机构：
[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Biomed Engn, Ctr Neural Engn, Cleveland, OH 44106 USA
来源：
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS | 2012年 / 22卷 / 03期
关键词：
Stimulation; epilepsy; seizure; synchrony; entrainment; hippocampus; DEEP BRAIN-STIMULATION; FUNCTIONAL CONNECTIONS; AXONAL CONDUCTION; NETWORK DYNAMICS; EPILEPSY; VITRO; SEIZURES; RAT; DISCHARGES; CHAOS;
D O I：
10.1142/S0129065712500062
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the stimulation entrained the hippocampal network's spontaneous epileptiform activity and disrupted its bilateral synchrony.
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页数：14
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