A NOVEL ELECTRICAL STIMULATION PARADIGM FOR THE SUPPRESSION OF EPILEPTIFORM ACTIVITY IN AN IN VIVO MODEL OF MESIAL TEMPORAL LOBE STATUS EPILEPTICUS

被引：23
|
作者：
Tang, Yuang [1 ]
Durand, Dominique M. [2 ]
机构：
[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Biomed Engn, Ctr Neural Engn, Cleveland, OH 44106 USA
来源：
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS | 2012年 / 22卷 / 03期
关键词：
Stimulation; epilepsy; seizure; synchrony; entrainment; hippocampus; DEEP BRAIN-STIMULATION; FUNCTIONAL CONNECTIONS; AXONAL CONDUCTION; NETWORK DYNAMICS; EPILEPSY; VITRO; SEIZURES; RAT; DISCHARGES; CHAOS;
D O I：
10.1142/S0129065712500062
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the stimulation entrained the hippocampal network's spontaneous epileptiform activity and disrupted its bilateral synchrony.
引用
收藏
页数：14
相关论文
共 50 条
  • [31] Characterising seizure development, behavioural comorbidities and neuroinflammation in a self-sustained electrical status epilepticus model of mesial temporal lobe epilepsy in C57BL/6J mice
    Thergarajan, Peravina
    Hudson, Matthew R.
    Carmichael, Irena
    Classadonte, Jerome
    Dedeurwaerdere, Stefanie
    O'Brien, Terence J.
    Jones, Nigel C.
    Ali, Idrish
    NEUROBIOLOGY OF DISEASE, 2022, 168
  • [32] Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy
    Widmann, Melanie
    Lieb, Andreas
    Mutti, Anna
    Schwarzer, Christoph
    EPILEPSY RESEARCH, 2023, 197
  • [33] Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy
    Pace, JR
    Lonser, RR
    Kirkby, RD
    Jeffries, N
    Rogawski, MA
    Oldfield, EH
    JOURNAL OF NEUROSURGERY, 2002, 97 (02) : 450 - 454
  • [34] A knowledge-based approach for automatic quantification of epileptiform activity in children with electrical status epilepticus during sleep
    Zhao, Xian
    Wang, Xinhua
    Chen, Chen
    Fan, Jiahao
    Yu, Xilin
    Wang, Zeyu
    Akbarzadeh, Saeed
    Li, Qiang
    Zhou, Shuizhen
    Chen, Wei
    JOURNAL OF NEURAL ENGINEERING, 2020, 17 (04)
  • [35] Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy
    Hakimova, Hilola
    Kim, Sangwoo
    Chu, Kon
    Lee, Sang Kun
    Jeong, Bumseok
    Jeon, Daejong
    EPILEPSY & BEHAVIOR, 2015, 49 : 26 - 32
  • [36] Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy
    Paschen, Enya
    Elgueta, Claudio
    Heining, Katharina
    Vieira, Diego M.
    Kleis, Piret
    Orcinha, Catarina
    Haeussler, Ute
    Bartos, Marlene
    Egert, Ulrich
    Janz, Philipp
    Haas, Carola A.
    ELIFE, 2020, 9
  • [37] Epileptiform activity but not synaptic plasticity is blocked by oxidation of NMDA receptors in a chronic model of temporal lobe epilepsy
    Quesada, O
    Hirsch, JC
    Gozlan, H
    BenAri, Y
    Bernard, C
    EPILEPSY RESEARCH, 1997, 26 (02) : 373 - 380
  • [38] Effect of continuous electrical focus stimulation to the amygdala in a model of temporal lobe epilepsy.
    Urino, T
    Hori, T
    Kato, T
    Yoshida, A
    Hashizume, K
    Tanaka, T
    EPILEPSIA, 2004, 45 : 77 - 77
  • [39] A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat
    Nissinen, J
    Halonen, T
    Koivisto, E
    Pitkänen, A
    EPILEPSY RESEARCH, 2000, 38 (2-3) : 177 - 205
  • [40] LONG-DURATION SELF-SUSTAINED EPILEPTIFORM ACTIVITY IN THE HIPPOCAMPAL PARAHIPPOCAMPAL SLICE - A MODEL OF STATUS EPILEPTICUS
    RAFIQ, A
    ZHANG, YF
    DELORENZO, RJ
    COULTER, DA
    JOURNAL OF NEUROPHYSIOLOGY, 1995, 74 (05) : 2028 - 2042
12345