Viral proteins function as ion channels

被引：99

作者：

Wang, Kai ^{[1
]}

Xie, Shiqi ^{[1
]}

Sun, Bing ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Mol Virol Lab, Shanghai 200025, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2011年 / 1808卷 / 02期

关键词：

Viral ion channels; PBCV-1; Influenza; HIV-1; HCV; Picornavirus; Coronavirus; HEPATITIS-C-VIRUS; INFLUENZA-A VIRUS; CORONAVIRUS ENVELOPE PROTEIN; COXSACKIEVIRUS 2B PROTEIN; INTEGRAL MEMBRANE GLYCOPROTEIN; MODULATING CYCLOPHILIN LIGAND; ESCHERICHIA-COLI-CELLS; M-2 PROTON CHANNEL; VPU PROTEIN; M2; PROTEIN;

D O I：

10.1016/j.bbamem.2010.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral ion channels are short membrane proteins with 50-120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：510 / 515

页数：6

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