Viral proteins function as ion channels

被引：99
|
作者：
Wang, Kai [1 ]
Xie, Shiqi [1 ]
Sun, Bing [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Mol Virol Lab, Shanghai 200025, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2011年 / 1808卷 / 02期
关键词：
Viral ion channels; PBCV-1; Influenza; HIV-1; HCV; Picornavirus; Coronavirus; HEPATITIS-C-VIRUS; INFLUENZA-A VIRUS; CORONAVIRUS ENVELOPE PROTEIN; COXSACKIEVIRUS 2B PROTEIN; INTEGRAL MEMBRANE GLYCOPROTEIN; MODULATING CYCLOPHILIN LIGAND; ESCHERICHIA-COLI-CELLS; M-2 PROTON CHANNEL; VPU PROTEIN; M2; PROTEIN;
D O I：
10.1016/j.bbamem.2010.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Viral ion channels are short membrane proteins with 50-120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：510 / 515
页数：6
相关论文
共 50 条
  • [21] REGULATION OF ION CHANNELS BY G-PROTEINS
    BOCKAERT, J
    M S-MEDECINE SCIENCES, 1989, 5 (08): : 562 - 569
  • [22] Multiple Scales in the Simulation of Ion Channels and Proteins
    Eisenberg, Bob
    JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (48): : 20719 - 20733
  • [23] Ion channels go to Stockholm - This time as proteins
    Miller, C
    NEURON, 2003, 40 (06) : 1049 - 1051
  • [24] TRP ion channels: Proteins with conformational flexibility
    Elena Lopez-Romero, Ana
    Hernandez-Araiza, Ileana
    Torres-Quiroz, Francisco
    Tovar-Y-Romo, Luis B.
    Islas, Leon D.
    Rosenbaum, Tamara
    CHANNELS, 2019, 13 (01) : 207 - 226
  • [25] Optogenetic Modulation of Ion Channels by Photoreceptive Proteins
    Tsukamoto, Hisao
    Furutani, Yuji
    OPTOGENETICS: LIGHT-SENSING PROTEINS AND THEIR APPLICATIONS IN NEUROSCIENCE AND BEYOND, 2ND EDITION, 2021, 1293 : 73 - 88
  • [26] Structure and function of water and ion channels
    Fujiyoshi, Y
    JOURNAL OF NEUROCHEMISTRY, 2003, 87 : 30 - 30
  • [27] The atomic structure and function of ion channels
    MacKinnon, R
    FASEB JOURNAL, 2003, 17 (04): : A1 - A1
  • [28] Ion channels: Function unravelled by dysfunction
    Thomas J. Jentsch
    Christian A. Hübner
    Jens C. Fuhrmann
    Nature Cell Biology, 2004, 6 : 1039 - 1047
  • [29] Function and selectivity of ion channels.
    Rempe, SB
    Pratt, LR
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U163 - U163
  • [30] Ion channels and lymphatic vessel function
    Bodtkjer, Donna M. B.
    Telenius, N.
    Mohanakumar, S.
    Majgaard, J.
    Skov, F.
    Lee, S.
    Hjortdal, V.
    Aalkjaer, C.
    ACTA PHYSIOLOGICA, 2015, 215 : 37 - 37
12345