Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer

被引:37
|
作者
Schaap, D. P. [1 ,6 ]
de Valk, K. S. [2 ,3 ,7 ,11 ]
Deken, M. M. [2 ,3 ,11 ]
Meijer, R. P. J. [2 ,3 ,7 ,11 ]
Burggraaf, J. [2 ,7 ]
Vahrmeijer, A. L. [3 ,11 ]
Kusters, M. [4 ,5 ]
Boogerd, L. S. F. [5 ,11 ]
Voogt, E. L. K. [6 ]
Nieuwenhuijzen, G. A. P. [6 ]
Rutten, H. J. T. [6 ]
de Hingh, I. H. J. T. [6 ]
Burger, J. W. A. [6 ]
Nienhuijs, S. W. [6 ]
Brandt-Kerkhof, A. R. M. [8 ]
Verhoef, C. [8 ]
Madsen, E. V. E. [8 ]
van Kooten, J. P. [8 ]
Framery, B. [9 ]
Gutowski, M. [9 ]
Pelegrin, A. [9 ]
Cailler, F. [9 ]
van Lijnschoten, I [10 ]
Hoogstins, C. E. S. [11 ]
机构
[1] Catharina Hosp, Dept Surg, Eindhoven, Netherlands
[2] Leiden Univ, Med Ctr, Ctr Human Drug Res, Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands
[4] Locat VUmc, Dept Surg, Amsterdam Univ, Med Ctr, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
[5] Locat VUmc, Med Ctr, Amsterdam Univ, Amsterdam, Netherlands
[6] Catharina Hosp, Eindhoven, Netherlands
[7] Ctr Human Drug Res, Leiden, Netherlands
[8] Erasmus Univ, Med Ctr, Rotterdam, Netherlands
[9] SurgiMab, Montpellier, France
[10] PAMM Lab Pathol & Med Microbiol, Eindhoven, Netherlands
[11] Leiden Univ, Med Ctr, Leiden, Netherlands
关键词
PERITONEAL CARCINOMATOSIS; SURVIVAL; ORIGIN; MANAGEMENT;
D O I
10.1002/bjs.11523
中图分类号
R61 [外科手术学];
学科分类号
摘要
This multicentre pilot study investigated the role of peroperative carcinoembryonic antigen (CEA)-specific fluorescence imaging during cytoreductive surgery-hyperthermic intraperitoneal chemotherapy surgery in peritoneal metastasized colorectal cancer. A correct change in peritoneal carcinomatosis index (PCI) owing to fluorescence imaging was seen in four of the 14 included patients. The use of SGM-101 in patients with peritoneally metastasized colorectal carcinoma is feasible, and allows intraoperative detection of tumour deposits and alteration of the PCI. Augmented reality guidance
引用
收藏
页码:334 / 337
页数:4
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