Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer

被引：37

作者：

Schaap, D. P. ^{[1
,6
]}

de Valk, K. S. ^{[2
,3
,7
,11
]}

Deken, M. M. ^{[2
,3
,11
]}

Meijer, R. P. J. ^{[2
,3
,7
,11
]}

Burggraaf, J. ^{[2
,7
]}

Vahrmeijer, A. L. ^{[3
,11
]}

Kusters, M. ^{[4
,5
]}

Boogerd, L. S. F. ^{[5
,11
]}

Voogt, E. L. K. ^{[6
]}

Nieuwenhuijzen, G. A. P. ^{[6
]}

Rutten, H. J. T. ^{[6
]}

de Hingh, I. H. J. T. ^{[6
]}

Burger, J. W. A. ^{[6
]}

Nienhuijs, S. W. ^{[6
]}

Brandt-Kerkhof, A. R. M. ^{[8
]}

Verhoef, C. ^{[8
]}

Madsen, E. V. E. ^{[8
]}

van Kooten, J. P. ^{[8
]}

Framery, B. ^{[9
]}

Gutowski, M. ^{[9
]}

Pelegrin, A. ^{[9
]}

Cailler, F. ^{[9
]}

van Lijnschoten, I ^{[10
]}

Hoogstins, C. E. S. ^{[11
]}

机构：

[1] Catharina Hosp, Dept Surg, Eindhoven, Netherlands

[2] Leiden Univ, Med Ctr, Ctr Human Drug Res, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[4] Locat VUmc, Dept Surg, Amsterdam Univ, Med Ctr, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[5] Locat VUmc, Med Ctr, Amsterdam Univ, Amsterdam, Netherlands

[6] Catharina Hosp, Eindhoven, Netherlands

[7] Ctr Human Drug Res, Leiden, Netherlands

[8] Erasmus Univ, Med Ctr, Rotterdam, Netherlands

[9] SurgiMab, Montpellier, France

[10] PAMM Lab Pathol & Med Microbiol, Eindhoven, Netherlands

[11] Leiden Univ, Med Ctr, Leiden, Netherlands

来源：

BRITISH JOURNAL OF SURGERY | 2020年 / 107卷 / 04期

关键词：

PERITONEAL CARCINOMATOSIS; SURVIVAL; ORIGIN; MANAGEMENT;

D O I：

10.1002/bjs.11523

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This multicentre pilot study investigated the role of peroperative carcinoembryonic antigen (CEA)-specific fluorescence imaging during cytoreductive surgery-hyperthermic intraperitoneal chemotherapy surgery in peritoneal metastasized colorectal cancer. A correct change in peritoneal carcinomatosis index (PCI) owing to fluorescence imaging was seen in four of the 14 included patients. The use of SGM-101 in patients with peritoneally metastasized colorectal carcinoma is feasible, and allows intraoperative detection of tumour deposits and alteration of the PCI. Augmented reality guidance

引用

页码：334 / 337

页数：4

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