Validation of analytical methodology for simultaneous evaluation of mebendazole and thiabendazole in tablets by high performance liquid chromatography

被引：0
|
作者：
de Paula, Nubia K. [1 ]
Sena, Marcelo M. [1 ]
机构：
[1] Univ Estadual Goias, Unidade Univ Ciencias Exatas & Tecnol, BR-75000000 Anapolis, Go, Brazil
来源：
QUIMICA NOVA | 2007年 / 30卷 / 05期
关键词：
HPLC; quality control; benzimidazoles;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this work was to develop and validate an analytical methodology for simultaneous determination of mebendazole and thiabendazole, two benzimidazoles used as anthelmintics. The method was based on high performance liquid chromatography, using a C18 column, a mobile phase composod of KH2PO4 0.05 mol L-1 and methanol 40:60 (v/v) and UV detection at 312 nm. The results showed that the method presented linearity from 60.0 to 140.0 mu g mL(-1) for mebendazole and from 99.6 to 232.4 g mu L-1 for thiabendazole and it was considered selective, accurate, precise and robust according to the specific resolution from ANVISA, the Brazilian regulatory agency.
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页码：1359 / 1361
页数：3
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