Validation of analytical methodology for simultaneous evaluation of mebendazole and thiabendazole in tablets by high performance liquid chromatography

被引：0
|
作者：
de Paula, Nubia K. [1 ]
Sena, Marcelo M. [1 ]
机构：
[1] Univ Estadual Goias, Unidade Univ Ciencias Exatas & Tecnol, BR-75000000 Anapolis, Go, Brazil
来源：
QUIMICA NOVA | 2007年 / 30卷 / 05期
关键词：
HPLC; quality control; benzimidazoles;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of this work was to develop and validate an analytical methodology for simultaneous determination of mebendazole and thiabendazole, two benzimidazoles used as anthelmintics. The method was based on high performance liquid chromatography, using a C18 column, a mobile phase composod of KH2PO4 0.05 mol L-1 and methanol 40:60 (v/v) and UV detection at 312 nm. The results showed that the method presented linearity from 60.0 to 140.0 mu g mL(-1) for mebendazole and from 99.6 to 232.4 g mu L-1 for thiabendazole and it was considered selective, accurate, precise and robust according to the specific resolution from ANVISA, the Brazilian regulatory agency.
引用
收藏
页码：1359 / 1361
页数：3
相关论文
共 50 条
  • [21] Simultaneous determination of desloratadine and pseudoephedrine sulfate in tablets by high performance liquid chromatography and derivative spectrophotometry
    Caglar, Sena
    Toker, Sidika Erturk
    REVIEWS IN ANALYTICAL CHEMISTRY, 2011, 30 (3-4) : 145 - 151
  • [22] SIMULTANEOUS DETERMINATION OF BROMVALETONE AND PROPANTHELINE BROMIDE IN TABLETS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    TZOU, MC
    HO, C
    JOURNAL OF LIQUID CHROMATOGRAPHY, 1992, 15 (09): : 1577 - 1591
  • [23] Determination of leflunomide in tablets by high performance liquid chromatography
    Yeniceli, D
    Dogrukol-Ak, D
    Tuncel, M
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (01) : 197 - 201
  • [24] Development and validation of high-performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets
    Mahmoudi, Abdelghani
    De Francia, Silvia
    Paul, Prasanta
    JOURNAL OF SEPARATION SCIENCE, 2023, 46 (21)
  • [25] Development and validation of high-performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets
    Mahmoudi, Abdelghani
    De Francia, Silvia
    Paul, Prasanta
    JOURNAL OF SEPARATION SCIENCE, 2023,
  • [26] Simultaneous assay of olanzapine and Fluoxetine in tablets by column high-performance liquid chromatography and high-performance thin-layer chromatography
    Shah, Charmy R.
    Shah, Nehal J.
    Suhagia, Bhanubhai N.
    Patel, Natvarlal M.
    JOURNAL OF AOAC INTERNATIONAL, 2007, 90 (06) : 1573 - 1578
  • [27] Simultaneous Determination of Levamisole, Mebendazole, and the Two Metabolite Residues of Mebendazole in Poultry Eggs by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
    Chen, Lan
    He, Zhaoyuan
    Zhang, Peiyang
    Guo, Yawen
    Lu, Yang
    Tang, Yayun
    Chen, Jinyuan
    Xie, Kaizhou
    SEPARATIONS, 2022, 9 (04)
  • [28] ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF OXYBENZONE, OCTOCRYLENE, OCTINOXATE AND AVOBENZONE IN SUNSCREEN BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND ITS VALIDATION
    Bhuva, Chirag
    Singh, Rambir
    Sharma, Anil
    PHARMACOPHORE, 2012, 3 (02): : 130 - 155
  • [29] DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR DETERMINATION OF TIBOLONE IN CAPSULES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
    da Rosa, Hernandez Bozardi
    Tolotti, Renata Cristine
    Miron, Diogo dos Santos
    Borges de Souza, Kellen Cristhinia
    QUIMICA NOVA, 2012, 35 (05): : 1030 - 1035
  • [30] DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
    de Lima Gomes, Elionai Cassiana
    Cunha Junior, Armando da Silva
    Yoshida, Maria Irene
    Jorge, Rodrigo
    QUIMICA NOVA, 2012, 35 (03): : 608 - 611
12345