Inhibition of big endothelin-1 (BIG ET-1) responses in endothelium-denuded human coronary artery by the selective endothelin-converting enzyme-1 (ECE-1) inhibitor PD159790

被引:0
|
作者
Maguire, JJ
Ahn, K
Davenport, AP
机构
[1] Univ Cambridge, Addenbrookes Hosp, Ctr Clin Investigat, Clin Pharmacol Unit, Cambridge CB2 2QQ, England
[2] Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
193P
引用
收藏
页码:U102 / U102
页数:1
相关论文
共 50 条
  • [41] Transcriptional and signaling mechanisms of isoform-specific expression of the gene for endothelin-converting enzyme-1 (ECE-1) in human endothelial cells
    Orzechowski, HD
    Zimmermann, A
    Günther, A
    Funke-Kaiser, H
    Paul, M
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2002, 365 : R8 - R8
  • [42] Gene regulation of endothelin-1 (ET-1) and endothelin converting enzyme (ECE) in Streptozotocin (STZ) diabetic rats.
    Takeyama, M
    Kohda, Y
    Nonoguchi, H
    Nakayama, Y
    Kitamura, K
    Nakayama, K
    Tomita, K
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A3166 - A3166
  • [43] Endothelin-1 and endothelin-converting enzyme-1 in human granulomatous pathology of eyelid:: an immunohistochemical and in situ hybridization study in chalazia
    Massai, L.
    Volpi, N.
    Carbotti, P.
    Fruschelli, M.
    Mencarelli, M.
    Pecorelli, A.
    Muscettola, M.
    Agliano, M.
    Alessandrini, C.
    Grasso, G.
    HISTOLOGY AND HISTOPATHOLOGY, 2007, 22 (12) : 1343 - 1354
  • [44] The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1
    Raoch, V.
    Martinez-Miguel, P.
    Arribas-Gomez, I.
    Rodriguez-Puyol, M.
    Rodriguez-Puyol, D.
    Lopez-Ongil, S.
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (03) : 313 - 322
  • [45] Effect of an antisense oligodeoxynucleotide to endothelin-converting enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 protein and endothelin-1 synthesis in bovine pulmonary artery smooth muscle cells
    Barker, S
    Khan, NQ
    Wood, EG
    Corder, R
    MOLECULAR PHARMACOLOGY, 2001, 59 (02) : 163 - 169
  • [46] Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease
    Maguire, JJ
    Davenport, AP
    BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (02) : 238 - 240
  • [47] The cytosolic spliced variant of endothelin-converting enzyme-1 is reduced in Alzheimer's disease and the ECE-1 transcript is increased in vascular dementia
    Palmer, J. C.
    Kehoe, P. G.
    Love, S.
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2009, 35 : 22 - 22
  • [48] Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1 (1-21) and ET-1 (1-31) in the trachea of allergic mice
    De Campo, BA
    Goldie, RG
    Jeng, AY
    Henry, PJ
    CLINICAL SCIENCE, 2002, 103 : 353S - 356S
  • [49] Constrictor responses of the novel peptide human urotensin II (U-II) and endothelin-1 (ET-1) compared in endothelium-denuded human arteries and veins in vitro
    Maguire, JJ
    Davenport, AP
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 : U21 - U21
  • [50] BIG ENDOTHELIN-1 STRUCTURE IMPORTANT FOR SPECIFIC PROCESSING BY ENDOTHELIN-CONVERTING ENZYME OF BOVINE ENDOTHELIAL-CELLS
    OKADA, K
    ARAI, Y
    HATA, M
    MATSUYAMA, K
    YANO, M
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 218 (02): : 493 - 498