Comparison of eosinophilic cationic protein, adiponectin and leptin levels in patients with allergic rhinitis and local allergic rhinitis Comparison of adipokin levels in patients with allergic rhinitis and local allergic rhinitis

Aim: Local allergic rhinitis (LAR) is a type of rhinitis with unclear treatment and unknown incidence and mechanism, which is characterized by perennial rhinitis complaints. A nasal provocation test (NPT) is recommended in the diagnosis of LAR. Eosinophil cationic protein (ECP), leptin, and adiponectin tests are markers reported to be used in the diagnosis and treatment of many allergic diseases. In this study, we aimed to investigate whether there is a difference in serum adiponectin, leptin, and ECP levels between patients with allergic rhinitis (AR) and LAR. Material and Methods: Adult patients aged 18-65 years, who had been complaining of rhinitis for at least two years, had perennial rhinitis complaints were included in the study. Results: NPT was positive in 30% of the patients; 30% (9 patients) of the patients who had non-allergic rhinitis and underwent NPT were found to have a positive nasal provocation test A significant difference was determined between the groups in terms of ECP and adiponectin levels (p: 0.001 and p: 0.007). There was a significant difference between the patients with AR and NPT (-) LAR in terms of ECP levels (p: 0.001). Furthermore, a significant difference was determined between patients with NPT (+) LAR and NPT (-) LAR and patients with NPT (+) LAR and the control group in terms of ECP levels (p: 0.001 and p: 0.001). Discussion: Although ECP and adiponectin levels differ between patient groups, it is obvious that larger studies are needed to evaluate the correlation of these parameters with the severity of rhinitis in patients with rhinitis.