Update on local allergic rhinitis

被引：12

作者：

Altintoprak, Niyazi ^{[1
]}

Kar, Murat ^{[2
]}

Muluk, Nuray Bayar ^{[3
]}

Oktemer, Tugba ^{[4
]}

Ipci, Kagan ^{[5
]}

Birdane, Leman ^{[6
]}

Aricigil, Mitat ^{[7
]}

Senturk, Mehmet ^{[8
]}

Bafaqeeh, Sameer Ali ^{[9
]}

Cingi, Cemal ^{[10
]}

机构：

[1] Tuzla State Hosp, ENT Clin, Istanbul, Turkey

[2] Kumluca State Hosp, ENT Clin, Antalya, Turkey

[3] Kirikkale Univ, Fac Med, Dept Otorhinolaryngol, Kirikkale, Turkey

[4] Private Polath Can Hosp, ENT Clin, Polatli Ankara, Turkey

[5] Ankara Koru Hosp, ENT Clin, Ankara, Turkey

[6] Yunus Emre State Hosp, ENT Clin, Eskisehir, Turkey

[7] Necmettin Erbakan Univ, Meram Med Fac, ENT Dept, Konya, Turkey

[8] Konya Training & Res Hosp, ENT Clin, Konya, Turkey

[9] King Saud Univ, ENT Dept, Riyadh, Saudi Arabia

[10] Eskisehir Osmangazi Univ, Fac Med, Dept Otorhinolaryngol, Eskisehir, Turkey

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2016年 / 87卷

关键词：

Local allergic rhinitis; Absence; Systemic atopy; Local production; Specific IgE; Antibodies; Mechanism; AZELASTINE NASAL SPRAY; INTRANASAL FLUTICASONE PROPIONATE; PERSISTENT NONALLERGIC RHINITIS; IDIOPATHIC RHINITIS; PROVOCATION TEST; OCULAR SYMPTOMS; MESSENGER-RNA; MAST-CELLS; EFFICACY; IGE;

D O I：

10.1016/j.ijporl.2016.06.008

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：105 / 109

页数：5

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