Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes

被引：17

作者：

Li, Liang ^{[1
,2
,3
]}

Wang, Guan-Wu ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[3] Hefei Normal Univ, Dept Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 20期

基金：

中国国家自然科学基金;

关键词：

CARBONYLATIVE CYCLIZATION REACTIONS; PALLADIUM-CATALYZED ANNULATION; H BOND FUNCTIONALIZATION; C-H; MEDICINAL MECHANOCHEMISTRY; EFFICIENT SYNTHESIS; PROMOTED SYNTHESIS; INTERNAL ALKYNES; SUZUKI-MIYAURA; CARBOANNULATION;

D O I：

10.1021/acs.joc.1c01472

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The mechanochemical solvent-free synthesis of indenones from aromatic carboxylic acids and alkynes was achieved through triflic anhydride (Tf2O)-induced cyclization reaction. A variety of indenones including a bioactive PPAR gamma agonist were obtained in up to 90% yield at room temperature. The present protocol has the advantages of mild reaction conditions, high reaction efficiency, and feasibility of scalable synthesis, providing a facile and sustainable route to diverse indenones.

引用

页码：14102 / 14112

页数：11

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