Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes

被引：17
|
作者：
Li, Liang [1 ,2 ,3 ]
Wang, Guan-Wu [1 ,2 ]
机构：
[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[3] Hefei Normal Univ, Dept Chem & Chem Engn, Hefei 230601, Anhui, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 20期
基金：
中国国家自然科学基金;
关键词：
CARBONYLATIVE CYCLIZATION REACTIONS; PALLADIUM-CATALYZED ANNULATION; H BOND FUNCTIONALIZATION; C-H; MEDICINAL MECHANOCHEMISTRY; EFFICIENT SYNTHESIS; PROMOTED SYNTHESIS; INTERNAL ALKYNES; SUZUKI-MIYAURA; CARBOANNULATION;
D O I：
10.1021/acs.joc.1c01472
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The mechanochemical solvent-free synthesis of indenones from aromatic carboxylic acids and alkynes was achieved through triflic anhydride (Tf2O)-induced cyclization reaction. A variety of indenones including a bioactive PPAR gamma agonist were obtained in up to 90% yield at room temperature. The present protocol has the advantages of mild reaction conditions, high reaction efficiency, and feasibility of scalable synthesis, providing a facile and sustainable route to diverse indenones.
引用
收藏
页码：14102 / 14112
页数：11
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