Effect of dimethyl sulfoxide on DNA conformation in solution

被引：0
|
作者：
Kosmotynskaya, YV [1 ]
Bogdanov, AA [1 ]
Kas'yanenko, NA [1 ]
机构：
[1] St Petersburg State Univ, St Petersburg, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY | 2005年 / 79卷
关键词：
D O I：
暂无
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
DNA conformations in aqueous solutions containing various dimethyl sulfoxide (DMSO) concentrations were studied. Small (to 7 vol %) DMSO concentrations do not affect the spectroscopic characteristics, volume, or persistent length of a DNA molecule. Higher DMSO concentrations alter the circular dichroism (CD) spectra of the DNA. The optical anisotropy of the macromolecule changes, and the coil volume decreases, but the double-helix DNA structure is not noticeably perturbed. DMSO effects on native and denatured DNA are compared.
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页码：S86 / S89
页数：4
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