Effect of dimethyl sulfoxide on DNA conformation in solution

被引：0

作者：

Kosmotynskaya, YV ^{[1
]}

Bogdanov, AA ^{[1
]}

Kas'yanenko, NA ^{[1
]}

机构：

[1] St Petersburg State Univ, St Petersburg, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY | 2005年 / 79卷

关键词：

D O I：

暂无

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

DNA conformations in aqueous solutions containing various dimethyl sulfoxide (DMSO) concentrations were studied. Small (to 7 vol %) DMSO concentrations do not affect the spectroscopic characteristics, volume, or persistent length of a DNA molecule. Higher DMSO concentrations alter the circular dichroism (CD) spectra of the DNA. The optical anisotropy of the macromolecule changes, and the coil volume decreases, but the double-helix DNA structure is not noticeably perturbed. DMSO effects on native and denatured DNA are compared.

引用

页码：S86 / S89

页数：4

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