An Aqueous Extract of Withania somnifera Root Inhibits Amyloid β Fibril Formation In Vitro

被引：34

作者：

Kumar, Suresh ^{[1
,2
]}

Harris, Robin J. ^{[3
,4
]}

Seal, Christopher J. ^{[1
]}

Okello, Edward J. ^{[1
,5
]}

机构：

[1] Newcastle Univ, Sch Agr Food & Rural Dev, Med Plant Res Grp, Fac Sci Agr & Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] GGS Indraprastha Univ, Univ Sch Biotechnol, New Delhi 110075, India

[3] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Johannes Gutenberg Univ Mainz, Inst Zool, D-55099 Mainz, Germany

[5] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 01期

关键词：

Alzheimer's disease; amyloid beta; fibrillogenesis; W; somnifera; ALZHEIMERS-DISEASE; OXIDATIVE DAMAGE; PROTEIN; CYTOTOXICITY; MECHANISMS; CLEARANCE; PEPTIDE; BINDING; CORTEX; MICE;

D O I：

10.1002/ptr.3512

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ability of an aqueous extract of W. somnifera L. Dunal (Family: Solanaceae) roots to inhibit fibril formation by the amyloid-beta peptide in vitro was investigated. W. somnifera is used extensively in traditional Ayurvedic medicine as a nerve tonic with reputed memory enhancing properties. Inhibition of fibrillogenesis measured by transmission electron microscopy and ThT fluorescence assay showed that an aqueous extract of W. somnifera strongly inhibited A beta fibril formation in a concentration-dependent manner, when compared with control samples. These results suggest that the aqueous extract of W. somnifera root has an ability to inhibit the formation of mature amyloid-beta fibrils in vitro, which are known to lead to amyloid plaque formation in vivo. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：113 / 117

页数：5

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