CEREBROSPINAL-FLUID INHIBITS ALZHEIMER BETA-AMYLOID FIBRIL FORMATION IN-VITRO

被引：59
|
作者：
WISNIEWSKI, T [1 ]
CASTANO, E [1 ]
GHISO, J [1 ]
FRANGIONE, B [1 ]
机构：
[1] NYU MED CTR,DEPT PATHOL,NEW YORK,NY 10016
来源：
ANNALS OF NEUROLOGY | 1993年 / 34卷 / 04期
关键词：
D O I：
10.1002/ana.410340422
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Alzheimer's disease is characterized by the deposition of beta-protein (Abeta) as amyloid. Recently, it was found that Abeta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to Abeta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to Abeta1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.
引用
下载
收藏
页码：631 / 633
页数：3
相关论文
共 50 条
  • [1] Cerebrospinal fluid of Alzheimer patients promotes β-amyloid fibril formation in vitro
    Ono, K
    Noguchi, M
    Matsumoto, Y
    Yanase, D
    Iwasa, K
    Naiki, H
    Yamada, M
    NEUROBIOLOGY OF DISEASE, 2005, 20 (02) : 233 - 240
  • [2] BETA-AMYLOID PROTEIN IN CEREBROSPINAL-FLUID OF ALZHEIMER-DISEASE - CORRELATIONS WITH MMSE
    CHANG, L
    MILLER, BL
    SCHARRE, DW
    CUMMINGS, J
    VIGOPELFRY, C
    SCHENK, D
    NEUROLOGY, 1994, 44 (04) : A206 - A206
  • [3] Acetylcholinesterase promotes Alzheimer beta-amyloid fibril formation
    Inestrosa, NC
    Alvarez, A
    Garrido, J
    Calderon, F
    Bronfman, FC
    Dajas, F
    Gentry, MK
    Doctor, BP
    ALZHEIMER'S DISEASE: BIOLOGY, DIAGNOSIS AND THERAPEUTICS, 1997, : 499 - 508
  • [4] Cerebrospinal fluid and plasma of Alzheimer patients promote β-amyloid fibril formation in vitro
    Ono, K.
    Noguchi-Shinohara, M.
    Samuraki, M.
    Matsumoto, Y.
    Yanase, D.
    Iwasa, K.
    Naiki, H.
    Yamada, M.
    XIth International Symposium on Amyloidosis, 2008, : 25 - 26
  • [5] Cerebrospinal fluid and plasma of Alzheimer patients promote β-amyloid fibril formation in vitro
    Ono, K.
    Noguchi-Shinohara, M.
    Samuraki, M.
    Matsumoto, Y.
    Yanase, D.
    Iwasa, K.
    Naiki, H.
    Yamada, M.
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2006, 13 : 50 - 50
  • [6] CHARACTERIZATION OF BETA-AMYLOID PEPTIDE FROM HUMAN CEREBROSPINAL-FLUID
    VIGOPELFREY, C
    LEE, D
    KEIM, P
    LIEBERBURG, I
    SCHENK, DB
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 (05) : 1965 - 1968
  • [7] AMYLOID-BETA BINDING-PROTEINS IN-VITRO AND IN NORMAL HUMAN CEREBROSPINAL-FLUID
    GOLABEK, A
    MARQUES, MA
    LALOWSKI, M
    WISNIEWSKI, T
    NEUROSCIENCE LETTERS, 1995, 191 (1-2) : 79 - 82
  • [8] AN AGE-RELATED CORRELATION BETWEEN LEVELS OF BETA-AMYLOID PRECURSOR PROTEIN AND BETA-AMYLOID IN HUMAN CEREBROSPINAL-FLUID
    CARROLL, RT
    LUST, MR
    KIM, KS
    DOYLE, PD
    EMMERLING, MR
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 210 (02) : 345 - 349
  • [9] DEVELOPMENTAL AND AGE-RELATED-CHANGES IN THE LEVELS OF BETA-AMYLOID AND BETA-AMYLOID PRECURSOR PROTEIN IN HUMAN CEREBROSPINAL-FLUID
    CARROLL, RT
    KIM, KS
    WISNIEWSKI, HM
    LUST, MR
    KREIMERBIRNBAUM, M
    DOYLE, PD
    EMMERLING, MR
    NEUROBIOLOGY OF AGING, 1994, 15 : S158 - S158
  • [10] ALPHA(1)-ANTICHYMOTRYPSIN REGULATES ALZHEIMER BETA-AMYLOID PEPTIDE FIBRIL FORMATION
    ERIKSSON, S
    JANCIAUSKIENE, S
    LANNFELT, L
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) : 2313 - 2317
12345