CEREBROSPINAL-FLUID INHIBITS ALZHEIMER BETA-AMYLOID FIBRIL FORMATION IN-VITRO

被引：59
|
作者：
WISNIEWSKI, T [1 ]
CASTANO, E [1 ]
GHISO, J [1 ]
FRANGIONE, B [1 ]
机构：
[1] NYU MED CTR,DEPT PATHOL,NEW YORK,NY 10016
来源：
ANNALS OF NEUROLOGY | 1993年 / 34卷 / 04期
关键词：
D O I：
10.1002/ana.410340422
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Alzheimer's disease is characterized by the deposition of beta-protein (Abeta) as amyloid. Recently, it was found that Abeta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to Abeta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to Abeta1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.
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页码：631 / 633
页数：3
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