MEDI 452-Discovery of nicotinamides and related derivatives as potent and selective NCX reverse mode inhibitors

被引:0
|
作者
Kakefuda, Akio [1 ]
Kuramochi, Takahiro [1 ]
Yamada, Hiroyoshi [1 ]
Sato, Ippei [1 ]
Tsukamoto, Issei [1 ]
Taguchi, Taku [2 ]
Sakamoto, Shuichi [3 ]
机构
[1] Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan
[2] Astellas Pharma Inc, QA, RA & Pharmacovigilance, Itabashi Ku, Tokyo 1748612, Japan
[3] Astellas Pharma Inc, Technol, Itabashi Ku, Tokyo 1748612, Japan
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
452-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
    Jiang, Xiangyi
    Huang, Boshi
    Rumrill, Shawn
    Pople, David
    Zalloum, Waleed A.
    Kang, Dongwei
    Zhao, Fabao
    Ji, Xiangkai
    Gao, Zhen
    Hu, Lide
    Wang, Zhao
    Xie, Minghui
    De Clercq, Erik
    Ruiz, Francesc X.
    Arnold, Eddy
    Pannecouque, Christophe
    Liu, Xinyong
    Zhan, Peng
    COMMUNICATIONS CHEMISTRY, 2023, 6 (01)
  • [22] Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
    Xiangyi Jiang
    Boshi Huang
    Shawn Rumrill
    David Pople
    Waleed A. Zalloum
    Dongwei Kang
    Fabao Zhao
    Xiangkai Ji
    Zhen Gao
    Lide Hu
    Zhao Wang
    Minghui Xie
    Erik De Clercq
    Francesc X. Ruiz
    Eddy Arnold
    Christophe Pannecouque
    Xinyong Liu
    Peng Zhan
    Communications Chemistry, 6
  • [23] MEDI 372-Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase
    Romero, Karma
    Geuns-Meyer, Stephanie
    Hughes, Paul
    Bak, Annette
    Bellon, Steve
    Bready, James
    Caenepeel, Sean
    Cee, Victor J.
    Chaffee, Stuart C.
    Coxon, Angela
    Deak, Holly L.
    Emery, Maurice
    Fretland, Jenne
    Gallant, Paul
    Gu, Yan
    Hodous, Brian L.
    Hoffman, Doug
    Johnson, Rebecca E.
    Kendall, Richard
    Kim, Joseph L.
    Lin, Jasmine
    Long, Alexander M.
    Morrison, Michael
    Nguyen, Hanh N.
    Olivieri, Philip R., II
    Patel, Vinod F.
    Polverino, Anthony
    Powers, David
    Rose, Paul
    Stanton, Mary K.
    Wang, Ling
    Zhao, Huilin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [24] Discovery of potent and selective Ros1 inhibitors with a unique DFG-out binding mode
    Mevellec, Laurence
    Wroblowski, Berthold
    Gilissen, Ron
    Descamps, Sophie
    Pasquier, Elisabeth
    Adelinet, Christophe
    Bourgeois, Marine
    Mercey, Guillaume
    Jeanty, Matthieu
    Jousseaume, Thierry
    Luguern, Aurelie
    Gandara, Javier Astray
    Akzinnay, Said
    Daras, Etienne
    Boeckx, Inge
    Van Slycken, Nele
    Bekkers, Mariette
    Van De Ven, Jeroen
    Verhulst, Tinne
    Meerpoel, Lieven
    Vialard, Jorge
    CANCER RESEARCH, 2014, 74 (19)
  • [25] Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors
    Jin, Fangfang
    Hu, Qiyue
    Fei, Hongbo
    Lv, Hejun
    Wang, Shenglan
    Gui, Bin
    Zhang, Junzhen
    Tu, Wangyang
    Zhang, Yun
    Zhang, Lei
    Wan, Hong
    Zhang, Limin
    Hu, Bin
    Yang, Fanglong
    Bai, Chang
    He, Feng
    Zhang, Lianshan
    Tao, Weikang
    ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (02): : 195 - 201
  • [26] Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors
    Gellibert, F.
    Fouchet, M. -H.
    Nguyen, V. -L.
    Wang, R.
    Krysa, G.
    de Gouville, A. -C.
    Huet, S.
    Dodic, N.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (08) : 2277 - 2281
  • [27] Discovery of novel hydroxamates as highly potent and selective TACE inhibitiors: Part II - SAR development of mode A inhibitors
    Zhu, Z
    Mazzola, R
    Sinning, L
    Lavey, B
    Zhou, GW
    Spitler, J
    Wong, SC
    Orth, P
    Guo, ZY
    Kong, J
    Liang, X
    Wong, J
    Kozlowski, J
    McKittrick, B
    Shih, NY
    Sun, J
    Chen, SC
    Niu, XD
    Sullivan, L
    Lundell, D
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2670 - U2670
  • [28] MEDI 52-Discovery of novel oxadiazolyl phenyl derivatives as herpes helicase-primase inhibitors with potent activity against HSV and VZV
    Kontani, Toru
    Miyata-Sato, Junji
    Hamaguchi, Wataru
    Kamikawa, Akio
    Kawano, Tomoaki
    Suzuki, Hiroshi
    Sudo, Kenji
    Takeuchi, Makoto
    Ohta, Mitsuaki
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [29] Discovery of Pyridine-2-Carboxamides Derivatives as Potent and Selective HPK1 Inhibitors for the Treatment of Cancer
    Peng, Jingjing
    Ding, Xiaoyu
    Chen, Celia Xiaojing
    Zhao, Pei
    Ding, Xiao
    Zhang, Man
    Aliper, Alex
    Ren, Feng
    Lu, Hongfu
    Zhavoronkov, Alex
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (23) : 21520 - 21544
  • [30] Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant Resistance
    Wang, Yazhou
    Zhang, Yihong
    Liu, Jinxin
    Zhao, Jichen
    Wang, Chao
    Meng, Fanye
    Cai, Xin
    Zhang, Man
    Aliper, Alex
    Liang, Tao
    Yan, Feng
    Ren, Feng
    Lan, Jiong
    Lu, Qiang
    Zhou, Fusheng
    Zhavoronkov, Alex
    Ding, Xiao
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (03) : 3886 - 3899