Highly enantioselective bioreduction of N-methyl-3-oxo-3-(thiophen-2-yl) propanamide for the production of (S)-duloxetine

被引：10

作者：

Tang, Chuan-Gen ^{[1
,2
]}

Lin, Hui ^{[1
,2
]}

Zhang, Chao ^{[1
]}

Liu, Zhang-Qin ^{[1
]}

Yang, Tao ^{[1
]}

Wu, Zhong-Liu ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2011年 / 33卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Bioreduction; Duloxetine; Ketoreductase; Rhodotorula glutinis; HYDROGENATION; DULOXETINE; REDUCTION;

D O I：

10.1007/s10529-011-0578-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Whole cells of Rhodotorula glutinis reduced N-methyl-3-oxo-3-(thiophen-2-yl) propanamide at 30 g/l to (S)-N-methyl-3-hydroxy-3-(2-thienyl) propionamide, an intermediate in the production of (S)-duloxetine, a blockbuster antidepressant drug, in 48 h. The reaction had excellent enantioselectivity (single enantiomer, > 99.5% enantiomeric excess [ee]) with a > 95% conversion.

引用

页码：1435 / 1440

页数：6

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