Highly enantioselective bioreduction of N-methyl-3-oxo-3-(thiophen-2-yl) propanamide for the production of (S)-duloxetine

被引：10
|
作者：
Tang, Chuan-Gen [1 ,2 ]
Lin, Hui [1 ,2 ]
Zhang, Chao [1 ]
Liu, Zhang-Qin [1 ]
Yang, Tao [1 ]
Wu, Zhong-Liu [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2011年 / 33卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Bioreduction; Duloxetine; Ketoreductase; Rhodotorula glutinis; HYDROGENATION; DULOXETINE; REDUCTION;
D O I：
10.1007/s10529-011-0578-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Whole cells of Rhodotorula glutinis reduced N-methyl-3-oxo-3-(thiophen-2-yl) propanamide at 30 g/l to (S)-N-methyl-3-hydroxy-3-(2-thienyl) propionamide, an intermediate in the production of (S)-duloxetine, a blockbuster antidepressant drug, in 48 h. The reaction had excellent enantioselectivity (single enantiomer, > 99.5% enantiomeric excess [ee]) with a > 95% conversion.
引用
收藏
页码：1435 / 1440
页数：6
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