Open-Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy

被引：97

作者：

Wang, Han ^{[1
]}

Guo, Jinxiao ^{[2
]}

Lin, Wilson ^{[3
,4
]}

Fu, Zi ^{[1
]}

Ji, Xiuru ^{[1
]}

Yu, Bo ^{[3
,4
]}

Lu, Min ^{[1
]}

Cui, Wenguo ^{[1
]}

Deng, Lianfu ^{[1
]}

Engle, Jonathan W. ^{[3
,4
]}

Wu, Zhiyuan ^{[5
]}

Cai, Weibo ^{[3
,4
]}

Ni, Dalong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med,Ruijin Hosp, Dept Orthopaed,Shanghai Inst Traumatol & Orthopae, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China

[3] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA

[4] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

[5] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Intervent Radiol, Shanghai 200025, Peoples R China

来源：

ADVANCED MATERIALS | 2022年 / 34卷 / 15期

基金：

中国博士后科学基金; 中国国家自然科学基金; 美国国家卫生研究院;

关键词：

glutathione response; nanomedicine; open shell; positron emission tomography imaging; sonodynamic therapy;

D O I：

10.1002/adma.202110283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Deleterious effects to normal tissues and short biological half-life of sonosensitizers limit the applications of sonodynamic therapy (SDT). Herein, a new sonosensitizer (Cu(II)NS) is synthesized that consists of porphyrins, chelated Cu2+, and poly(ethylene glycol) (PEG) to overcome the challenges of SDT. As Cu2+ contains 27 electrons, Cu(II)NS has an unpaired electron (open shell), resulting in a doublet ground state and little sonosensitivity. Overexpressed glutathione in the tumor can reduce Cu2+ to generate Cu(I)NS, leading to a singlet ground state and recuperative sonosensitivity. Additionally, PEG endows Cu(II)NS with increased blood biological half-life and enhanced tumor accumulation, further increasing the effect of SDT. Through regulating the valence state of Cu, cancer SDT with enhanced therapeutic index is achieved.

引用

页数：8

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