Copper-Catalyzed Decarboxylative Atom Transfer Radical Addition of Iododifluoroacetate to Alkynyl Carboxylic Acids

被引：70

作者：

Li, Gang ^{[1
]}

Cao, Yi-Xuan ^{[1
]}

Luo, Chen-Guang ^{[1
]}

Su, Yi-Ming ^{[1
]}

Li, Yan ^{[1
]}

Lan, Quan ^{[1
]}

Wang, Xi-Sheng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Self Assembly Chem Organ Funct, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 19期

基金：

美国国家科学基金会;

关键词：

H-PHOSPHINE OXIDES; MEDIATED TRIFLUOROMETHYLATION; COUPLING REACTION; TERMINAL ALKYNES; FACILE SYNTHESIS; EFFICIENT; ALKENES; FLUORINE; DIFLUOROMETHYLATION; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.6b02216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of copper-catalyzed decarboxylative atom transfer radical addition of alkynyl carboxylic acids has been developed with a readily available fluoroalkyl halide. This novel protocol has demonstrated a unique difunctionalization of nonterminal alkynes with a broad substrate scope and excellent functional-group tolerance. Mechanistic investigations revealed that the catalytic cycle was initiated by the attack of a difluoroalkyl radical to an in situ generated alkynylcopper species.

引用

页码：4806 / 4809

页数：4

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