Palladium-Catalyzed Decarboxylative Trifluoroethylation of Aryl Alkynyl Carboxylic Acids

被引：62
|
作者：
Hwang, Jinil [1 ]
Park, Kyungho [1 ]
Choe, Juseok [1 ]
Min, Hongkeun [1 ]
Song, Kwang Ho [2 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea
[2] Korea Univ, Dept Chem & Biol Engn, Seoul 136713, South Korea
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
TERMINAL ALKYNES; ELECTROPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; MEDIATED FLUORINATION; UNACTIVATED ALKENES; COUPLING REACTIONS; HALIDES; AMINOFLUORINATION; STRATEGY; CARBON;
D O I：
10.1021/jo5003032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(eta(3)-allyl)Cl](2)/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 degrees C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.
引用
收藏
页码：3267 / 3271
页数：5
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