Remote Alkenylation via Carbopalladation/1,4-Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols

被引：2
|
作者：
Chen, Su [1 ]
Van der Eycken, Erik V. [1 ,2 ]
Sharma, Upendra K. [1 ]
机构：
[1] Univ Leuven KU Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[2] RUDN Univ, Peoples Friendship Univ Russia, Miklukho Maklaya St 6, RU-117198 Moscow, Russia
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 09期
关键词：
Pd-catalysis; remote alkenylation; 1,4-Pd migration; carbopalladation; C-H activation; C-H ACTIVATION; ALLYL ALCOHOLS; HECK REACTION; 1,4-PALLADIUM MIGRATION; EFFICIENT SYNTHESIS; DOMINO REACTION; PALLADIUM; ARYL; ARYLATION; 1,4-MIGRATION;
D O I：
10.1002/adsc.202200126
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Intramolecular C-H bond activation via 1,4-palladium migration has become a synthetic tool to enable remote functionalization of C-H bonds. In this work, we report a Pd-catalyzed remote alkenylation with unactivated alkenyl alcohols involving a 1,4-palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcohols in a single operational step.
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页码：1543 / 1548
页数：6
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