Remote Alkenylation via Carbopalladation/1,4-Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols

被引：2

作者：

Chen, Su ^{[1
]}

Van der Eycken, Erik V. ^{[1
,2
]}

Sharma, Upendra K. ^{[1
]}

机构：

[1] Univ Leuven KU Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[2] RUDN Univ, Peoples Friendship Univ Russia, Miklukho Maklaya St 6, RU-117198 Moscow, Russia

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 09期

关键词：

Pd-catalysis; remote alkenylation; 1,4-Pd migration; carbopalladation; C-H activation; C-H ACTIVATION; ALLYL ALCOHOLS; HECK REACTION; 1,4-PALLADIUM MIGRATION; EFFICIENT SYNTHESIS; DOMINO REACTION; PALLADIUM; ARYL; ARYLATION; 1,4-MIGRATION;

D O I：

10.1002/adsc.202200126

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Intramolecular C-H bond activation via 1,4-palladium migration has become a synthetic tool to enable remote functionalization of C-H bonds. In this work, we report a Pd-catalyzed remote alkenylation with unactivated alkenyl alcohols involving a 1,4-palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcohols in a single operational step.

引用

页码：1543 / 1548

页数：6

共 35 条

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[27] Palladium-Catalyzed C-H Alkenylation of Arenes with Alkynes: Stereoselective Synthesis of Vinyl Chlorides via a 1,4-Chlorine Migration
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[28] Ligand-Enabled Palladium-Catalyzed Through-Space C-H Bond Activation via a Carbopalladation/1,4-Pd Migration/C-H Functionalization Sequence
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