PEOPLE (NTC03447678), a phase II trial of first-line, single-agent pembrolizumab in advanced NSCLC with low PD-L1: Clinical outcomes and association with circulating immune biomarkers.

被引:0
|
作者
Lo Russo, Giuseppe
Ganzinelli, Monica
Sgambelluri, Francesco
Galli, Francesca
Prelaj, Arsela
Manglaviti, Sara
Bottiglieri, Achille
Di Mauro, Rosa Maria
Ferrara, Roberto
Dumitrascu, Andra Diana
Sottotetti, Elisa
Martinetti, Antonia
Fabbri, Alessandra
Rulli, Eliana
De Braud, Filippo G.
Torri, Valter
Garassino, Marina Chiara
Anichini, Andrea
Proto, Claudia
Mortarini, Roberta
机构
[1] Fdn IRCCS Ist Nazl Tumori, Thorac Oncol Unit, Milan, Italy
[2] Fdn IRCCS Ist Nazl Tumori, Dept Med Oncol, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Milan, Italy
[4] IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy
[5] Ist Nazl Tumori, Milan, Italy
[6] Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy
[7] NCI, Milan, Italy
[8] Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy
[9] Fdn IRCCS Ist Nazl Tumori, Med Oncol Dept, ENETS Ctr Excellence, Milan, Italy
[10] Univ Milan, Oncol & Hemato Oncol Dept, Milan, Italy
[11] Mario Negri Inst Pharmacol Res IRCCS, Milan, Italy
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
9033
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Update results of anlotinib plus TQB2450 (PD-L1 blockade) combined with nab-paclitaxel and cisplatin as first-line treatment for advanced biliary tract cancer: A single-arm, open-label phase II clinical trial.
    Guo, Wen-Zhi
    Li, Lu-Hao
    Qiao, Shishi
    Li, Ren-Feng
    Zhang, Weijie
    He, Wei
    Su, Chang
    Pan, Jie
    Jin, Shui-Ling
    Zong, Hong
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [42] The preliminary data from a single-arm, open- label, multicenter phase II clinical trial: KN046 combined with axitinib as first-line (1L) treatment for NSCLC
    Zhao, Y.
    Huang, Y.
    Fang, W.
    Yang, Y.
    Shi, J.
    Zhao, H.
    Meng, X.
    Zhang, L.
    Liu, A.
    Xu, T.
    Liu, Y.
    Wang, N.
    Zhang, L.
    ANNALS OF ONCOLOGY, 2023, 34
  • [43] Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment including fluoropyrimidine, platinum, and anti-PD-1/PD-L1 antibody (PADDLE)
    Hirano, Hidekazu
    Takahashi, Naoki
    Amanuma, Yusuke
    Suzuki, Nobumi
    Takahari, Daisuke
    Kawakami, Takeshi
    Kudo-Saito, Chie
    Nagashima, Kengo
    Boku, Narikazu
    Kato, Ken
    Shoji, Hirokazu
    BMC CANCER, 2025, 25 (01)
  • [44] Single-agent pemetrexed or sequentially administered pemetrexed/gemcitabine as first-line chemotherapy for advanced non-small cell lung cancer (NSCLC) in elderly patients or patients ineligible for platinum-based chemotherapy: Preliminary results of a phase II randomized trial
    Gridelli, C.
    Reck, M.
    Gregorc, V.
    Migliorino, M.
    Muller, T. R.
    Manegold, C.
    Favaretto, A.
    Crucitta, E.
    Munoz, M.
    Cirri, L.
    Marini, L.
    Rossi, A.
    Koschel, G.
    ANNALS OF ONCOLOGY, 2005, 16 : 162 - 162
  • [45] First-line single-agent pembrolizumab for PD-L1-positive (tumor proportion score ≥ 50%) advanced non-small cell lung cancer in the real world: impact in brain metastasis: a national French multicentric cohort (ESCKEYP GFPC study)
    Descourt, Renaud
    Greillier, Laurent
    Perol, Maurice
    Ricordel, Charles
    Auliac, Jean-Bernard
    Falchero, Lionel
    Gervais, Radj
    Veillon, Remi
    Vieillot, Sabine
    Guisier, Florian
    Marcq, Marie
    Justeau, Gregoire
    Bigay-Game, Laurence
    Bernardi, Marie
    Fournel, Pierre
    Doubre, Helene
    Pinsolle, Julian
    Amrane, Karim
    Chouaid, Christos
    Decroisette, Chantal
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023, 72 (01) : 91 - 99
  • [46] Updated results of anlotinib combined with TQB2450 (PD-L1 blockade) as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): A single-arm, multicenter, open-label phase. clinical trial
    Zhang, Zhiye
    Meng, Xiangrui
    Yang, Xiuli
    Hong, Yong-Gui
    Xia, Jin
    Chen, Yunfang
    Wu, Tao
    Shan, Zheng-Zheng
    Fan, Qingxia
    Wang, Feng
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [47] First-line single-agent pembrolizumab for PD-L1-positive (tumor proportion score ≥ 50%) advanced non-small cell lung cancer in the real world: impact in brain metastasis: a national French multicentric cohort (ESCKEYP GFPC study)
    Renaud Descourt
    Laurent Greillier
    Maurice Perol
    Charles Ricordel
    Jean-Bernard Auliac
    Lionel Falchero
    Radj Gervais
    Rémi Veillon
    Sabine Vieillot
    Florian Guisier
    Marie Marcq
    Grégoire Justeau
    Laurence Bigay-Game
    Marie Bernardi
    Pierre Fournel
    Hélène Doubre
    Julian Pinsolle
    Karim Amrane
    Christos Chouaïd
    Chantal Decroisette
    Cancer Immunology, Immunotherapy, 2023, 72 : 91 - 99
  • [48] First line (1L) durvalumab in patients with PD-L1 positive, advanced non-small cell lung cancer (NSCLC) with a performance status of 2 (PS2): Primary analysis of the multicenter, single-arm phase II trial SAKK 19/17
    Mark, Michael Thomas
    Froesch, Patrizia
    Gysel, Katrin
    Rothschild, Sacha
    Addeo, Alfredo
    Ackermann, Christoph J.
    Chiquet, Sabrina
    Schneider, Martina
    Ribi, Karin
    Maranta, Angela Fischer
    Bastian, Sara
    Von Moos, Roger Anton Fredy
    Joerger, Markus
    Fruh, Martin
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [49] First line (1L) durvalumab in patients with PD-L1 positive, advanced non-small cell lung cancer (NSCLC) with a performance status of 2 (PS2). Primary analysis of the multicenter, single-arm phase II trial SAKK 19/17
    Mark, M.
    Froesch, P.
    Gysel, K.
    Rothschild, S.
    Addeo, A.
    Ackermann, C.
    Chiquet, S.
    Schneider, M.
    Ribi, K.
    Fischer, A.
    Bastian, S.
    von Moos, R.
    Joerger, M.
    Frueh, M.
    SWISS MEDICAL WEEKLY, 2023, 153 : 7S - 7S
  • [50] TROPION-Lung07: A phase III trial of datopotamab deruxtecan (Dato-DXd) plus pembrolizumab (pembro) with or without platinum chemotherapy (Pt-CT) as first-line (1L) therapy in advanced/metastatic (adv/met) non-small cell lung cancer (NSCLC) with PD-L1 expression
    Okamoto, I.
    Kuyama, S.
    Girard, N.
    Lu, S.
    Franke, F. A.
    Pan, E.
    Ren, N.
    Chen, A.
    Oputa, E.
    Lisberg, A. E.
    ANNALS OF ONCOLOGY, 2023, 34