PEOPLE (NTC03447678), a phase II trial of first-line, single-agent pembrolizumab in advanced NSCLC with low PD-L1: Clinical outcomes and association with circulating immune biomarkers.

被引:0
|
作者
Lo Russo, Giuseppe
Ganzinelli, Monica
Sgambelluri, Francesco
Galli, Francesca
Prelaj, Arsela
Manglaviti, Sara
Bottiglieri, Achille
Di Mauro, Rosa Maria
Ferrara, Roberto
Dumitrascu, Andra Diana
Sottotetti, Elisa
Martinetti, Antonia
Fabbri, Alessandra
Rulli, Eliana
De Braud, Filippo G.
Torri, Valter
Garassino, Marina Chiara
Anichini, Andrea
Proto, Claudia
Mortarini, Roberta
机构
[1] Fdn IRCCS Ist Nazl Tumori, Thorac Oncol Unit, Milan, Italy
[2] Fdn IRCCS Ist Nazl Tumori, Dept Med Oncol, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Milan, Italy
[4] IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy
[5] Ist Nazl Tumori, Milan, Italy
[6] Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy
[7] NCI, Milan, Italy
[8] Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy
[9] Fdn IRCCS Ist Nazl Tumori, Med Oncol Dept, ENETS Ctr Excellence, Milan, Italy
[10] Univ Milan, Oncol & Hemato Oncol Dept, Milan, Italy
[11] Mario Negri Inst Pharmacol Res IRCCS, Milan, Italy
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
9033
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Update results of anlotinib combined with TQB2450 (PD-L1 blockade) as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): A single-arm, multicenter, open-label phase II clinical trial
    Hong, G.
    Meng, X.
    Yang, X.
    Zhang, Z. Y.
    Xia, J.
    Chen, Y-F.
    Wu, T.
    Shan, Z.
    Fan, Q.
    Wang, F.
    ANNALS OF ONCOLOGY, 2023, 34 : S861 - S861
  • [32] Anlotinib plus TQB2450 (PD-L1 blockade) combined with nab-paclitaxel and cisplatin as first-line treatment for advanced biliary tract cancer: A single-arm, open-label phase II clinical trial
    Jin, Shui-Ling
    Qiao, Shishi
    Li, Ren-Feng
    Zhang, Weijie
    He, Wei
    Su, Chang
    Li, Lu-Hao
    Pan, Jie
    Guo, Wen-Zhi
    Zong, Hong
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 498 - 498
  • [33] Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry
    Cortellini, Alessio
    Brunetti, Leonardo
    Di Fazio, Giuseppina Rita
    Garbo, Edoardo
    Pinato, David J.
    Naidoo, Jarushka
    Katz, Artur
    Loza, Monica
    Neal, Joel W.
    Genova, Carlo
    Gettinger, Scott
    Kim, So Yeon
    Jayakrishnan, Ritujith
    El Zarif, Talal
    Russano, Marco
    Pecci, Federica
    Di Federico, Alessandro
    Awad, Mark
    Alessi, Joao, V
    Montrone, Michele
    Owen, Dwight Hall
    Signorelli, Diego
    Fidler, Mary Jo
    Li, Mingjia
    Camerini, Andrea
    De Giglio, Andrea
    Young, Lauren
    Vincenzi, Bruno
    Metro, Giulio
    Passiglia, Francesco
    Yendamuri, Sai
    Guida, Annalisa
    Ghidini, Michele
    Awosika, Nichola O.
    Napolitano, Andrea
    Fulgenzi, Claudia A. M.
    Grisanti, Salvatore
    Grossi, Francesco
    D'Incecco, Armida
    Josephides, Eleni
    Van Hemelrijck, Mieke
    Russo, Alessandro
    Gelibter, Alain
    Spinelli, Gianpaolo
    Verrico, Monica
    Tomasik, Bartlomiej
    Giusti, Raffaele
    Newsom-Davis, Thomas
    Bria, Emilio
    Sebastian, Martin
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2025, 13 (02)
  • [34] First-line durvalumab in patients with PD-L1 positive, advanced non-small cell lung cancer (NSCLC) with a performance status of 2 (PS2). Primary analysis of the multicenter, single-arm phase II trial SAKK 19/17
    Mark, Michael
    Froesch, Patrizia
    Gysel, Katrin
    Rothschild, Sacha I.
    Addeo, Alfredo
    Ackermann, Christoph J.
    Chiquet, Sabrina
    Schneider, Martina
    Ribi, Karin
    Maranta, Angela Fischer
    Bastian, Sara
    von Moos, Roger
    Joerger, Markus
    Frueh, Martin
    EUROPEAN JOURNAL OF CANCER, 2024, 200
  • [35] DEnosumab in combination with PD-1 checkpoint blockade for MAINtenance therapy of KRAS-mutant advanced NSCLC after first-line immunotherapy: A prospective, single-arm, phase II trial (DEMAIN)
    Li, H-S.
    Xu, H.
    Duan, J.
    Wang, Z.
    Zhong, J.
    Cui, Y-Y.
    Fang, Q.
    Lei, S-Y.
    Wang, Y.
    ANNALS OF ONCOLOGY, 2023, 34
  • [36] Update results of anlotinib combined with TQB2450 (PD-L1 blockade) as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): A single-arm, multicenter, open-label phase II clinical trial.
    Meng, Xiangrui
    Yang, Xiuli
    Hong, Yong-Gui
    Zhang, Zhiye
    Xia, Jin
    Chen, Yunfang
    Wu, Tao
    Shan, Zheng-Zheng
    Fan, Qingxia
    Wang, Feng
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [37] Pembrolizumab (pembro) versus platinum-based chemotherapy (chemo) as first-line therapy for advanced/metastatic NSCLC with a PD-L1 tumor proportion score (TPS) ≥ 1%: Open-label, phase 3 KEYNOTE-042 study.
    Lopes, Gilberto
    Wu, Yi-Long
    Kudaba, Iveta
    Kowalski, Dariusz
    Cho, Byoung Chul
    Castro, Gilberto
    Srimuninnimit, Vichien
    Bondarenko, Igor
    Kubota, Kaoru
    Lubiniecki, Gregory M.
    Zhang, Jin
    Kush, Debra A.
    Mok, Tony
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (18)
  • [38] Preliminary results of TQB2450 (PD-L1 blockade) plus anlotinib combined with oxaliplatin and capecitabine in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: A single-arm, multicenter phase II clinical trial.
    Li, Ning
    Deng, Wen-Ying
    Ma, Yi-Jie
    Bie, Liang-Yu
    Zhang, Chi
    Wei, Chen
    Luo, Suxia
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 : 367 - 367
  • [39] Anlotinib combined with TQB2450 (PD-L1 blockade) as first-line treatment for advanced esophageal squamous cell carcinoma (ESCC): A single-arm, multicenter, open-label phase. clinical trial.
    Yang, Xiuli
    Meng, Xiangrui
    Hong, Yong-Gui
    Zhang, Zhiye
    Xia, Jin
    Wu, Tao
    Chen, Yunfang
    Shan, Zheng-Zheng
    Fan, Qingxia
    Wang, Feng
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 : 377 - 377
  • [40] Randomized phase II study of pembrolizumab (P) alone versus pegilodecakin (PEG) in combination with P as first-line (1L) therapy in patients (pts) with stage IV non-small cell lung cancer (NSCLC) with high PD-L1 expression (CYPRESS 1).
    Spigel, David R.
    Shum, Merrill Kingman
    Schneider, Jeffrey Gary
    Jotte, Robert M.
    Eisenstein, Jennifer L.
    Bhanderi, Viralkumar K.
    Konduri, Kartik
    Hung, Annie
    Hozak, Rebecca R.
    Ferry, David Raymond
    Gandhi, Leena
    Chao, Bo H.
    Rybkin, Igor I.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)