Deep transcranial magnetic stimulation add-on for treatment of negative symptoms and cognitive deficits of schizophrenia: a feasibility study

被引：63
|
作者：
Levkovitz, Yechiel [1 ,2 ,3 ]
Rabany, Liron [1 ,2 ,4 ]
Harel, Eiran Vadim [1 ,2 ]
Zangen, Abraham [5 ]
机构：
[1] Shalvata Mental Hlth Care Ctr, Emot Cognit Res Ctr, Hod Hasharon, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Massachusetts Gen Hosp, Boston, MA 02114 USA
[4] Tel Aviv Univ, Gordon Fac Social Sci, IL-69978 Tel Aviv, Israel
[5] Weitzman Inst Sci, Dept Neurobiol, Rehovot, Israel
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2011年 / 14卷 / 07期
关键词：
Cognition; negative symptoms; schizophrenia; transcranial magnetic stimulation; BRAIN; RTMS;
D O I：
10.1017/S1461145711000642
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Treatment for negative symptoms and cognitive deficits, core elements of schizophrenia, remains inadequate. Stimulation of the prefrontal cortex via transcranial magnetic stimulation (TMS) yields only moderate results, possibly due to limited stimulation depth. Deep-TMS enables deeper and wider stimulation than before. This preliminary study is the first to examine deep-TMS as a possible add-on treatment for negative symptoms and cognitive deficits of schizophrenia. The effect of 20 daily deep-TMS sessions (20 Hz, 120% motor threshold) over the prefrontal cortex of 15 patients indicated improvement in cognition and negative symptoms that was maintained at 2-wk post-treatment follow-up.
引用
收藏
页码：991 / 996
页数：6
相关论文
共 50 条
  • [41] Excitatory Deep Repetitive Transcranial Magnetic Stimulation With H-coil as Add-on Treatment of Motor Symptoms in Parkinson's Disease: An Open Label, Pilot Study
    Spagnolo, F.
    Volonte, M. A.
    Fichera, M.
    Chieffo, R.
    Houdayer, E.
    Bianco, M.
    Coppi, E.
    Nuara, A.
    Straffi, L.
    Di Maggio, G.
    Ferrari, L.
    Libera, D. Dalla
    Velikova, S.
    Comi, G.
    Zangen, A.
    Leocani, L.
    BRAIN STIMULATION, 2014, 7 (02) : 297 - 300
  • [42] Repetitive transcranial magnetic stimulation in the treatment of chronic negative schizophrenia:: a pilot study
    Cohen, E
    Bernardo, M
    Masana, J
    Arrufat, FJ
    Navarro, V
    Valls-Solé, J
    Boget, T
    Barrantes, N
    Catarineu, S
    Font, M
    Lomeña, FJ
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 67 (01): : 129 - 130
  • [43] Can Repetitive Transcranial Magnetic Stimulation Be Considered Effective Treatment Option for Negative Symptoms of Schizophrenia?
    Prikryl, Radovan
    Kucerova, Hana Prikrylova
    JOURNAL OF ECT, 2013, 29 (01) : 67 - 74
  • [44] Cost-utility analysis of repetitive transcranial magnetic stimulation as add-on therapy to standard care for the treatment of hallucinations in schizophrenia
    Hendriks, Lauren
    Mihalopoulos, Cathrine
    Le, Long Khanh-Dao
    Loo, Colleen
    Chatterton, Mary Lou
    EUROPEAN PSYCHIATRY, 2022, 65 (01)
  • [45] Transcranial electrical brain stimulation methods for treatment of negative symptoms in schizophrenia
    Haller, Nikolas
    Hasan, Alkomiet
    Padberg, Frank
    Strube, Wolfgang
    da Costa Lane Valiengo, Leandro
    Brunoni, Andre R.
    Brunelin, Jerome
    Palm, Ulrich
    NERVENARZT, 2022, 93 (01): : 41 - 50
  • [46] Use of Transcranial Direct Stimulation (TDCS) in treatment of negative symptoms of schizophrenia
    Pontillo, M.
    Costanzo, F.
    Averna, R.
    Santonastaso, O.
    Tata, M. C.
    Menghini, D.
    Vicari, S.
    EUROPEAN PSYCHIATRY, 2018, 48 : S535 - S535
  • [47] Repetitive transcranial magnetic stimulation:: a putative add-on treatment for major depression in elderly patients
    Mosimann, UP
    Schmitt, W
    Greenberg, BD
    Kosel, M
    Müri, RM
    Berkhoff, M
    Hess, CW
    Fisch, HU
    Schlaepfer, TE
    PSYCHIATRY RESEARCH, 2004, 126 (02) : 123 - 133
  • [48] Mirtazapine Add-On Improves Olanzapine Effect on Negative Symptoms of Schizophrenia
    Caforio, Grazia
    Di Giorgio, Annabella
    Rampino, Antonio
    Rizzo, Miriam
    Romano, Raffaella
    Taurisano, Paolo
    Fazio, Leonardo
    De Simeis, Giuseppe
    Ursini, Gianluca
    Blasi, Giuseppe
    Nardini, Marcello
    Mancini, Michele
    Bertolino, Alessandro
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2013, 33 (06) : 810 - 812
  • [49] Treatment of negative symptoms of schizophrenia using repetitive transcranial magnetic stimulation in a double-blind, randomized controlled study
    Prikryl, Radovan
    Kasparek, Tomas
    Skotakova, Simona
    Ustohal, Libor
    Kucerova, Hana
    Ceskova, Eva
    SCHIZOPHRENIA RESEARCH, 2007, 95 (1-3) : 151 - 157
  • [50] TRANSCRANIAL MAGNETIC STIMULATION IN SCHIZOPHRENIA WITH PROMINENT NEGATIVE SYMPTOMS- A REVIEW OF THE LITERATURE
    Vasiliu, Octavian
    SCHIZOPHRENIA BULLETIN, 2020, 46 : S113 - S113
12345