Deep transcranial magnetic stimulation add-on for treatment of negative symptoms and cognitive deficits of schizophrenia: a feasibility study

被引：63

作者：

Levkovitz, Yechiel ^{[1
,2
,3
]}

Rabany, Liron ^{[1
,2
,4
]}

Harel, Eiran Vadim ^{[1
,2
]}

Zangen, Abraham ^{[5
]}

机构：

[1] Shalvata Mental Hlth Care Ctr, Emot Cognit Res Ctr, Hod Hasharon, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Massachusetts Gen Hosp, Boston, MA 02114 USA

[4] Tel Aviv Univ, Gordon Fac Social Sci, IL-69978 Tel Aviv, Israel

[5] Weitzman Inst Sci, Dept Neurobiol, Rehovot, Israel

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2011年 / 14卷 / 07期

关键词：

Cognition; negative symptoms; schizophrenia; transcranial magnetic stimulation; BRAIN; RTMS;

D O I：

10.1017/S1461145711000642

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Treatment for negative symptoms and cognitive deficits, core elements of schizophrenia, remains inadequate. Stimulation of the prefrontal cortex via transcranial magnetic stimulation (TMS) yields only moderate results, possibly due to limited stimulation depth. Deep-TMS enables deeper and wider stimulation than before. This preliminary study is the first to examine deep-TMS as a possible add-on treatment for negative symptoms and cognitive deficits of schizophrenia. The effect of 20 daily deep-TMS sessions (20 Hz, 120% motor threshold) over the prefrontal cortex of 15 patients indicated improvement in cognition and negative symptoms that was maintained at 2-wk post-treatment follow-up.

引用

页码：991 / 996

页数：6

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