Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

被引：10

作者：

Janasik, Dawid ^{[1
]}

Jasinski, Krzysztof ^{[2
]}

Weglarz, Wladyslaw P. ^{[2
]}

Nemec, Ivan ^{[3
,4
]}

Jewula, Pawel ^{[3
]}

Krawczyk, Tomasz ^{[1
]}

机构：

[1] Silesian Univ Technol Krzywoustego 4, Dept Chem Organ Technol & Petrochem, PL-44100 Gliwice, Poland

[2] Polish Acad Sci, Inst Nucl Phys, PL-31342 Krakow, Poland

[3] Brno Univ Technol, Cent European Inst Technol, Brno 61200, Czech Republic

[4] Palacky Univ 17, Fac Sci, Dept Inorgan Chem, Olomouc 77146, Czech Republic

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 08期

关键词：

SHIFT;

D O I：

10.1021/acs.analchem.1c04978

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.

引用

页码：3427 / 3431

页数：5

共 50 条

[41] Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents
Wang, Xia
Niu, Dechao
Wu, Qing
Bao, Song
Su, Teng
Liu, Xiaohang
Zhang, Shengjian
Wang, Qigang
BIOMATERIALS, 2015, 53 : 349 - 357
[42] Switchable MRI contrast agents based on morphological changes of pH-responsive polymers
Okada, Satoshi
Mizukami, Shin
Kikuchi, Kazuya
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (02) : 769 - 774
[43] Calcium-responsive contrast agents for functional magnetic resonance imaging
Miller, Austin D. C.
Ozbakir, Harun F.
Mukherjee, Arnab
CHEMICAL PHYSICS REVIEWS, 2021, 2 (02):
[44] Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia
Kadakia, Rahul T.
Xie, Da
Guo, Hongyu
Bouley, Bailey
Yu, Meng
Que, Emily L.
DALTON TRANSACTIONS, 2020, 49 (45) : 16419 - 16424
[45] Control of the radiofrequency field in fluorine (19F) magnetic resonance imaging
N. V. Anisimov
M. V. Gulyaev
D. V. Volkov
O. S. Pavlova
Yu. A. Pirogov
Physics of Wave Phenomena, 2015, 23 : 304 - 310
[46] Monitoring of inflammatory processes by in vivo 19F magnetic resonance imaging
Floegel, Ulrich
Ding, Zhaoping
Hardung, Hendrik
Jander, Sebastion
Reichwein, Gaby
Jacoby, Christoph
Schubert, Rolf
Schrader, Juergen
CIRCULATION, 2007, 116 (16) : 410 - 411
[47] A Multifunctional Contrast Agent for 19F-Based Magnetic Resonance Imaging
Du, Liang
Helsper, Shannon
Nosratabad, Neda Arabzadeh
Wang, Wentao
Fadool, Debra Ann
Amiens, Catherine
Grant, Samuel
Mattoussi, Hedi
BIOCONJUGATE CHEMISTRY, 2022, 33 (05) : 881 - 891
[48] Injectable hyaluronic acid hydrogel for 19F magnetic resonance imaging
Yang, Xia
Sun, Yi
Kootala, Sujit
Hilborn, Jons
Heerschap, Arend
Ossipov, Dmitri
CARBOHYDRATE POLYMERS, 2014, 110 : 95 - 99
[49] Control of the radiofrequency field in fluorine (19F) magnetic resonance imaging
Anisimov, N. V.
Gulyaev, M. V.
Volkov, D. V.
Pavlova, O. S.
Pirogov, Yu. A.
PHYSICS OF WAVE PHENOMENA, 2015, 23 (04) : 304 - 310
[50] Nickel(II) complexes of N-CH2CF3 cyclam derivatives as contrast agents for 19F magnetic resonance imaging
Blahut, Jan
Hermann, Petr
Galisova, Andrea
Herynek, Vit
Cisarova, Ivana
Tosner, Zdenek
Kotek, Jan
DALTON TRANSACTIONS, 2016, 45 (02) : 474 - 478

← 1 2 3 4 5 →