Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

被引：10
|
作者：
Janasik, Dawid [1 ]
Jasinski, Krzysztof [2 ]
Weglarz, Wladyslaw P. [2 ]
Nemec, Ivan [3 ,4 ]
Jewula, Pawel [3 ]
Krawczyk, Tomasz [1 ]
机构：
[1] Silesian Univ Technol Krzywoustego 4, Dept Chem Organ Technol & Petrochem, PL-44100 Gliwice, Poland
[2] Polish Acad Sci, Inst Nucl Phys, PL-31342 Krakow, Poland
[3] Brno Univ Technol, Cent European Inst Technol, Brno 61200, Czech Republic
[4] Palacky Univ 17, Fac Sci, Dept Inorgan Chem, Olomouc 77146, Czech Republic
来源：
ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 08期
关键词：
SHIFT;
D O I：
10.1021/acs.analchem.1c04978
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.
引用
收藏
页码：3427 / 3431
页数：5
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