Research progress on the pharmacological effects of matrine

被引：17

作者：

Sun, Yanan ^{[1
]}

Xu, Lu ^{[2
]}

Cai, Qihan ^{[2
]}

Wang, Mengmeng ^{[2
]}

Wang, Xinliang ^{[2
]}

Wang, Siming ^{[2
]}

Ni, Zhiyu ^{[3
,4
,5
]}

机构：

[1] Hebei Univ, Coll Tradit Chinese Med, Baoding, Peoples R China

[2] Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China

[3] Hebei Univ, Affiliated Hosp, Baoding, Peoples R China

[4] Hebei Univ, Clin Med Coll, Baoding, Peoples R China

[5] Hebei Collaborat Innovat Ctr Tumor Microecol Metab, Baoding, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷

关键词：

matrine; pharmacological action; toxicology; pharmacokinetics; gut and gut microbes; CANCER CELLS; OXIDATIVE STRESS; LUNG-CANCER; MOUSE MODEL; KAPPA-B; OXYMATRINE; PROLIFERATION; INFLAMMATION; ANTIOXIDANT; LIVER;

D O I：

10.3389/fnins.2022.977374

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and advanced glycation end products from the source by exerting anti-inflammatory and antioxidant effects; (3) protection of brain damage and cortical neurons by regulating apoptosis; (4) restoration of the intestinal barrier and regulation of the intestinal microbiota. This article aims to explore matrine's therapeutic potential by summarizing comprehensive information on matrine's pharmacology, toxicity, and bioavailability.

引用

页数：9

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