Research progress on the pharmacological effects of matrine

被引：17
|
作者：
Sun, Yanan [1 ]
Xu, Lu [2 ]
Cai, Qihan [2 ]
Wang, Mengmeng [2 ]
Wang, Xinliang [2 ]
Wang, Siming [2 ]
Ni, Zhiyu [3 ,4 ,5 ]
机构：
[1] Hebei Univ, Coll Tradit Chinese Med, Baoding, Peoples R China
[2] Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China
[3] Hebei Univ, Affiliated Hosp, Baoding, Peoples R China
[4] Hebei Univ, Clin Med Coll, Baoding, Peoples R China
[5] Hebei Collaborat Innovat Ctr Tumor Microecol Metab, Baoding, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷
关键词：
matrine; pharmacological action; toxicology; pharmacokinetics; gut and gut microbes; CANCER CELLS; OXIDATIVE STRESS; LUNG-CANCER; MOUSE MODEL; KAPPA-B; OXYMATRINE; PROLIFERATION; INFLAMMATION; ANTIOXIDANT; LIVER;
D O I：
10.3389/fnins.2022.977374
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and advanced glycation end products from the source by exerting anti-inflammatory and antioxidant effects; (3) protection of brain damage and cortical neurons by regulating apoptosis; (4) restoration of the intestinal barrier and regulation of the intestinal microbiota. This article aims to explore matrine's therapeutic potential by summarizing comprehensive information on matrine's pharmacology, toxicity, and bioavailability.
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页数：9
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