Efficient and stereoselective synthesis of novel cis 4-substituted proline analogues

被引：15
|
作者：
Zhang, JY
Wang, W
Xiong, CY
Hruby, VJ
机构：
[1] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
[2] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 07期
关键词：
proline; constrained amino acids; alkylation;
D O I：
10.1016/S0040-4039(02)02865-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the gamma-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1413 / 1415
页数：3
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