A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate

被引：18
|
作者：
Rasmussen, Megan L. [1 ]
Gama, Vivian [1 ,2 ,3 ,4 ]
机构：
[1] Vanderbilt Univ, Dept Cell & Dev Biol, 221 Kirkland Hall, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Med Ctr, Neurosci Program, Nashville, TN 37235 USA
[3] Vanderbilt Univ, Med Ctr, Vanderbilt Brain Inst, Nashville, TN 37235 USA
[4] Vanderbilt Univ, Vanderbilt Ctr Stem Cell Biol, 221 Kirkland Hall, Nashville, TN 37235 USA
来源：
CELL DEATH REGULATION IN HEALTH AND DISEASE - PT C | 2020年 / 353卷
关键词：
CYTOCHROME-C RELEASE; PROTEIN DRP1; PROTEOLYTIC CLEAVAGE; SYNAPSE FORMATION; QUALITY-CONTROL; OPA1; ISOFORMS; LIVING CELLS; X-L; FISSION; FUSION;
D O I：
10.1016/bs.ircmb.2019.12.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of apoptosis, also known as intrinsic apoptosis. Direct binding between members of the BCL-2 family regulates mitochondrial outer membrane permeabilization (MOMP) after an apoptotic insult. The ability of the cell to sense stress and translate it into a death signal has been a major theme of research for nearly three decades; however, other mechanisms by which the BCL-2 family coordinates cellular homeostasis beyond its role in initiating apoptosis are emerging. One developing area of research is understanding how the BCL-2 family of proteins regulate development using pluripotent stem cells as a model system. Understanding BCL-2 family-mediated regulation of mitochondrial homeostasis in cell death and beyond would uncover new facets of stem cell maintenance and differentiation potential.
引用
收藏
页码：255 / 284
页数：30
相关论文
共 50 条
  • [31] A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture
    Marc Pellegrini
    Andreas Strasser
    Journal of Clinical Immunology, 1999, 19 : 365 - 377
  • [32] Marked mitochondrial alterations upon starvation without cell death, caspases or Bcl-2 family members
    Kosta, Artemis
    Luciani, Marie-Francoise
    Geerts, Willie J. C.
    Golstein, Pierre
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (10): : 2013 - 2019
  • [33] Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
    Gurzov, Esteban N.
    Eizirik, Decio L.
    TRENDS IN CELL BIOLOGY, 2011, 21 (07) : 424 - 431
  • [34] Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary
    Tanner, Elizabeth A.
    Blute, Todd A.
    Brachmann, Carrie Baker
    McCall, Kimberly
    DEVELOPMENT, 2011, 138 (02): : 327 - 338
  • [35] Control of mitochondrial apoptosis by the Bcl-2 family
    Brunelle, Joslyn K.
    Letai, Anthony
    JOURNAL OF CELL SCIENCE, 2009, 122 (04) : 437 - 441
  • [36] The role of Bcl-2 family members in apoptotic cell death.
    Thompson, CB
    VanderHeiden, M
    Chang, BS
    Minn, AJ
    Sattler, M
    Liang, H
    Muchmore, SW
    Fesik, SW
    EXPERIMENTAL HEMATOLOGY, 1997, 25 (08) : 226 - 226
  • [37] BCL-2 GENE FAMILY AND THE REGULATION OF PROGRAMMED CELL-DEATH
    YIN, XM
    OLTVAI, ZN
    VEISNOVACK, DJ
    LINETTE, GP
    KORSMEYER, SJ
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 : 387 - 393
  • [38] Regulation of cell death in the lymphoid system by Bcl-2 family proteins
    Ivanovska, I
    Galonek, HL
    Hildeman, DA
    Hardwick, JM
    ACTA HAEMATOLOGICA, 2003, 111 (1-2) : 42 - 55
  • [39] The BCL-2 protein family: opposing activities that mediate cell death
    Richard J. Youle
    Andreas Strasser
    Nature Reviews Molecular Cell Biology, 2008, 9 : 47 - 59
  • [40] Role of Bcl-2 family members in anoxia induced cell death
    Shroff, Emelyn H.
    Snyder, Colleen
    Chandel, Navdeep S.
    CELL CYCLE, 2007, 6 (07) : 807 - 809
12345