A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate

被引:18
|
作者
Rasmussen, Megan L. [1 ]
Gama, Vivian [1 ,2 ,3 ,4 ]
机构
[1] Vanderbilt Univ, Dept Cell & Dev Biol, 221 Kirkland Hall, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Med Ctr, Neurosci Program, Nashville, TN 37235 USA
[3] Vanderbilt Univ, Med Ctr, Vanderbilt Brain Inst, Nashville, TN 37235 USA
[4] Vanderbilt Univ, Vanderbilt Ctr Stem Cell Biol, 221 Kirkland Hall, Nashville, TN 37235 USA
来源
CELL DEATH REGULATION IN HEALTH AND DISEASE - PT C | 2020年 / 353卷
关键词
CYTOCHROME-C RELEASE; PROTEIN DRP1; PROTEOLYTIC CLEAVAGE; SYNAPSE FORMATION; QUALITY-CONTROL; OPA1; ISOFORMS; LIVING CELLS; X-L; FISSION; FUSION;
D O I
10.1016/bs.ircmb.2019.12.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of apoptosis, also known as intrinsic apoptosis. Direct binding between members of the BCL-2 family regulates mitochondrial outer membrane permeabilization (MOMP) after an apoptotic insult. The ability of the cell to sense stress and translate it into a death signal has been a major theme of research for nearly three decades; however, other mechanisms by which the BCL-2 family coordinates cellular homeostasis beyond its role in initiating apoptosis are emerging. One developing area of research is understanding how the BCL-2 family of proteins regulate development using pluripotent stem cells as a model system. Understanding BCL-2 family-mediated regulation of mitochondrial homeostasis in cell death and beyond would uncover new facets of stem cell maintenance and differentiation potential.
引用
收藏
页码:255 / 284
页数:30
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