Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

被引：140
|
作者：
Zhang, Zhihong [1 ,2 ,4 ]
Cao, Weiguo [1 ,2 ,5 ]
Jin, Honglin [1 ,2 ,4 ]
Lovell, Jonathan F. [3 ]
Yang, Mi [1 ,2 ]
Ding, Lili [1 ,2 ]
Chen, Juan [1 ,2 ]
Corbin, Ian [1 ,2 ]
Luo, Qingming [4 ]
Zheng, Gang [1 ,2 ,3 ]
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada
[2] Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 1L7, Canada
[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5G 1L7, Canada
[4] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China
[5] Shanghai Univ, Dept Chem, Shanghai, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期
关键词：
biomimetic structures; cytosol; drug delivery; nanocarriers; peptides; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; SIRNA DELIVERY; SCAVENGER RECEPTOR; TARGETED DELIVERY; DENDRITIC CELLS; NANOPARTICLES; CARRIERS; CANCER; ATHEROSCLEROSIS;
D O I：
10.1002/anie.200903112
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9171 / 9175
页数：5
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