Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

被引：140

作者：

Zhang, Zhihong ^{[1
,2
,4
]}

Cao, Weiguo ^{[1
,2
,5
]}

Jin, Honglin ^{[1
,2
,4
]}

Lovell, Jonathan F. ^{[3
]}

Yang, Mi ^{[1
,2
]}

Ding, Lili ^{[1
,2
]}

Chen, Juan ^{[1
,2
]}

Corbin, Ian ^{[1
,2
]}

Luo, Qingming ^{[4
]}

Zheng, Gang ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 1L7, Canada

[3] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5G 1L7, Canada

[4] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China

[5] Shanghai Univ, Dept Chem, Shanghai, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期

关键词：

biomimetic structures; cytosol; drug delivery; nanocarriers; peptides; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; SIRNA DELIVERY; SCAVENGER RECEPTOR; TARGETED DELIVERY; DENDRITIC CELLS; NANOPARTICLES; CARRIERS; CANCER; ATHEROSCLEROSIS;

D O I：

10.1002/anie.200903112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9171 / 9175

页数：5

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