An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

被引：38
|
作者：
Onega, Mayca [1 ,2 ,3 ]
Domarkas, Juozas [3 ]
Deng, Hai [4 ]
Schweiger, Lutz F. [3 ]
Smith, Timothy A. D. [3 ]
Welch, Andrew E. [3 ]
Plisson, Christophe [5 ]
Gee, Antony D. [5 ]
O'Hagan, David [1 ,2 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Univ Aberdeen, John Mallard Scottish PET Ctr, Sch Med Sci, Aberdeen AB25 2ZD, Scotland
[4] Univ Aberdeen, UK Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland
[5] Univ London Imperial Coll Sci Technol & Med, GSK Clin Imaging Ctr, Hammersmith Hosp, London W12 0NN, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
NUCLEOSIDE HYDROLASE; L-TRYPTOPHAN; T; VIVAX; FLUORINASE; COMPLEX; PURINE; STATE; MECHANISM; TOOL;
D O I：
10.1039/b919364b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.
引用
收藏
页码：139 / 141
页数：3
相关论文
共 50 条
  • [41] Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma
    Martiniova, Lucia
    Cleary, Susannah
    Lai, Edwin W.
    Kiesewetter, Dale O.
    Seidel, Jurgen
    Dawson, Linda F.
    Phillips, Jacqueline K.
    Thomasson, David
    Chen, Xiaoyuan
    Eisenhofer, Graeme
    Powers, James F.
    Kvetnansky, Richard
    Pacak, Karel
    NUCLEAR MEDICINE AND BIOLOGY, 2012, 39 (02) : 215 - 226
  • [42] PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV)
    Parent, Maxime
    Bedard, Marc-Andre
    Aliaga, Antonio
    Soucy, Jean-Paul
    St-Pierre, Evelyne Landry
    Cyr, Marilyn
    Kostikov, Alexey
    Schirrmacher, Esther
    Massarweh, Gassan
    Rosa-Neto, Pedro
    NEUROIMAGE, 2012, 62 (01) : 555 - 561
  • [43] Comparison of [18F]DMFB and [18F] DMPY2 for PET imaging of melanoma
    Pyo, Ayoung
    Jung, Ye-Rim
    Kim, Dong-Yeon
    Min, Jung Joon
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019, 62 : S465 - S466
  • [44] Direct comparison of [18F]MH.MZ and [18F]altanserin for 5-HT2A receptor imaging with PET
    Hansen, Hanne D.
    Ettrup, Anders
    Herth, Matthias M.
    Dyssegaard, Agnete
    Ratner, Cecilia
    Gillings, Nic
    Knudsen, Gitte M.
    SYNAPSE, 2013, 67 (06) : 328 - 337
  • [45] Is 3′-deoxy-3′-[18F] fluorothymidine ([18F]-FLT) the next tracer for routine clinical PET after R [18F]-FDG?
    Couturier, O
    Leost, F
    Campone, M
    Carlier, T
    Chatal, JF
    Hustinx, R
    BULLETIN DU CANCER, 2005, 92 (09) : 789 - 798
  • [46] THE SYNTHESIS OF 6-DEOXY-6-[18F]FLUORO-D-FRUCTOSE FOR USE WITH PET
    Grant, T. N.
    Trayner, B.
    Cheeseman, C. I.
    West, F. G.
    Mercer, J.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2009, 52 : S190 - S190
  • [47] [18F]-2-Fluoro-2-Deoxy-D-glucose-PET Assessment of Cervical Cancer
    Viswanathan, Chitra
    Faria, Silvana
    Devine, Catherine
    Patnana, Madhavi
    Sagebiel, Tara
    Iyer, Revathy B.
    Bhosale, Priya R.
    PET CLINICS, 2018, 13 (02) : 165 - +
  • [48] Increased [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) yield with recycled target [18O]water:: factors affecting the [18F]FDG yield
    Nishijima, K
    Kuge, Y
    Tsukamoto, E
    Seki, K
    Ohkura, K
    Magata, Y
    Tanaka, A
    Nagatsu, K
    Tamaki, N
    APPLIED RADIATION AND ISOTOPES, 2002, 57 (01) : 43 - 49
  • [49] Use of 5'-deoxy-5'-[18F]fluoro-4-O-methylthymidine in the synthesis of 18F-labeled antisense oligodeoxynucleotide propbes for imaging gene expression with PET.
    Walsh, JC
    Pan, D
    Satyamurthy, N
    Barrio, JR
    Phelps, ME
    Toyokuni, T
    Gambhir, SS
    JOURNAL OF NUCLEAR MEDICINE, 2000, 41 (05) : 245P - 245P
  • [50] Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F]FDG and PET in combination with microdialysis
    Virtanen, KA
    Peltoniemi, P
    Marjamäki, P
    Asola, M
    Strindberg, L
    Parkkola, R
    Huupponen, R
    Knuuti, J
    Lönnroth, P
    Nuutila, P
    DIABETOLOGIA, 2001, 44 (12) : 2171 - 2179
12345