An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

被引：38

作者：

Onega, Mayca ^{[1
,2
,3
]}

Domarkas, Juozas ^{[3
]}

Deng, Hai ^{[4
]}

Schweiger, Lutz F. ^{[3
]}

Smith, Timothy A. D. ^{[3
]}

Welch, Andrew E. ^{[3
]}

Plisson, Christophe ^{[5
]}

Gee, Antony D. ^{[5
]}

O'Hagan, David ^{[1
,2
]}

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

[3] Univ Aberdeen, John Mallard Scottish PET Ctr, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

[4] Univ Aberdeen, UK Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland

[5] Univ London Imperial Coll Sci Technol & Med, GSK Clin Imaging Ctr, Hammersmith Hosp, London W12 0NN, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

NUCLEOSIDE HYDROLASE; L-TRYPTOPHAN; T; VIVAX; FLUORINASE; COMPLEX; PURINE; STATE; MECHANISM; TOOL;

D O I：

10.1039/b919364b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.

引用

页码：139 / 141

页数：3

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