An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

被引：38
|
作者：
Onega, Mayca [1 ,2 ,3 ]
Domarkas, Juozas [3 ]
Deng, Hai [4 ]
Schweiger, Lutz F. [3 ]
Smith, Timothy A. D. [3 ]
Welch, Andrew E. [3 ]
Plisson, Christophe [5 ]
Gee, Antony D. [5 ]
O'Hagan, David [1 ,2 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Univ Aberdeen, John Mallard Scottish PET Ctr, Sch Med Sci, Aberdeen AB25 2ZD, Scotland
[4] Univ Aberdeen, UK Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland
[5] Univ London Imperial Coll Sci Technol & Med, GSK Clin Imaging Ctr, Hammersmith Hosp, London W12 0NN, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
NUCLEOSIDE HYDROLASE; L-TRYPTOPHAN; T; VIVAX; FLUORINASE; COMPLEX; PURINE; STATE; MECHANISM; TOOL;
D O I：
10.1039/b919364b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5[F-18]fluororibose, a novel [F-18]-fluorinated sugar suitable for positron emission tomography (PET) applications.
引用
收藏
页码：139 / 141
页数：3
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