An efficient synthesis of cis-3-hydroxy-4-phenyl-beta-lactams: Precursor for taxol side chain

被引：41
|
作者：
Srirajan, V [1 ]
Deshmukh, ARAS [1 ]
Bhawal, BM [1 ]
机构：
[1] NATL CHEM LAB,DIV ORGAN CHEM SYNTH,POONA 411008,MAHARASHTRA,INDIA
来源：
TETRAHEDRON | 1996年 / 52卷 / 15期
关键词：
D O I：
10.1016/0040-4020(96)00200-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral ketene precursors derived from naturally occurring (+)-3-carene have been used for the synthesis of beta-lactams via the Staudinger reaction. The major diastereomer 5a was separated by crystallization and converted in very good yield into (3R, 4S)-3-hydroxy-4-phenyl-beta-lactam, an advanced intermediate towards the taxol side chain. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：5585 / 5590
页数：6
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