An efficient synthesis of cis-3-hydroxy-4-phenyl-beta-lactams: Precursor for taxol side chain

被引：41

作者：

Srirajan, V ^{[1
]}

Deshmukh, ARAS ^{[1
]}

Bhawal, BM ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM SYNTH,POONA 411008,MAHARASHTRA,INDIA

来源：

TETRAHEDRON | 1996年 / 52卷 / 15期

关键词：

D O I：

10.1016/0040-4020(96)00200-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral ketene precursors derived from naturally occurring (+)-3-carene have been used for the synthesis of beta-lactams via the Staudinger reaction. The major diastereomer 5a was separated by crystallization and converted in very good yield into (3R, 4S)-3-hydroxy-4-phenyl-beta-lactam, an advanced intermediate towards the taxol side chain. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5585 / 5590

页数：6

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