Synthesis and NMR analysis of 13C and 15N-labeled long-chain polyamines (LCPAs)

被引：4

作者：

Abacilar, Maryna ^{[1
]}

Daus, Fabian ^{[1
]}

Haas, Christian ^{[1
]}

Brueckner, Stephan Ingmar ^{[2
]}

Brunner, Eike ^{[2
]}

Geyer, Armin ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35032 Marburg, Germany

[2] Tech Univ Dresden, Fachrichtung Chem & Lebensmittelchem, D-01062 Dresden, Germany

来源：

RSC ADVANCES | 2016年 / 6卷 / 96期

关键词：

SILICA NANOSPHERES; DIATOM BIOSILICA; SPECTROSCOPY; REDUCTION; RESONANCE; CLEAVAGE; MILD;

D O I：

10.1039/c6ra19624a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-15, C-13, or both isotope labels were introduced in selected positions of several LCPAs containing 5, 11, or 13 nitrogens. The number of transformations during chemical synthesis wasminimized by coupling Fmoc-glycine-N-15, Fmoc-glycine-1-C-13, or Fmoc-beta-alanine simultaneously at both ends of the growing oligoamide chain on resin-linked norspermidine. LCPAs containing 10-20 nitrogens are the main organic constituent of diatom biosilica. Preliminary NMR studies of bioinspired silica nanocomposites obtained from double-labeled LCPA 14 and Si-29-enriched orthosilicic acid identified the close spatial arrangement of Si-29 and C-13 nuclei.

引用

页码：93343 / 93348

页数：6

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