Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid

被引：48
|
作者：
Vieregge, B [1 ]
Resch, K [1 ]
Kaever, V [1 ]
机构：
[1] Med Hsch Hannover, Inst Klin Mol Pharmakol, D-30623 Hannover, Germany
来源：
PLANTA MEDICA | 1999年 / 65卷 / 01期
关键词：
D O I：
10.1055/s-2006-960446
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The alkaloid sinomenine extracted from the medicinal plant Sinomenium acutum is used in China for the treatment of various rheumatic diseases, It has immunomodulatory properties in a cardiac allograft transplantation model. Its antiproliferative effect on human mononuclear cells in combination with different immunosuppressive drugs was further analysed in vitro. Sinomenine dose-dependently attenuated thymidine incorporation, interleukin-2 synthesis, and cell cycle progression of activated T-lymphocytes. Cell proliferation was synergistically decreased by addition of sinomenine together with suboptimal concentrations of the established immunosuppressive drugs tacrolimus or mycophenolic acid, respectively.
引用
收藏
页码：80 / 82
页数：3
相关论文
共 50 条
  • [31] In vitro and in vivo immunomodulatory effects of Cobalt protoporphyrin administered in combination with immunosuppressive drugs
    Besenzon, Federica
    Dedja, Arben
    Vadori, Marta
    Bosio, Erika
    Seveso, Michela
    Tognato, Elena
    Polito, Luigino
    Calabrese, Fiorella
    Valente, Marialuisa
    Rigotti, Paolo
    Ancona, Ermanno
    Cozzi, Emanuele
    TRANSPLANT IMMUNOLOGY, 2010, 24 (01) : 1 - 8
  • [32] INVITRO IMMUNOSUPPRESSIVE EFFECTS OF MYCOPHENOLIC-ACID AND AN ESTER PRO-DRUG, RS-61443
    ALLISON, AC
    ALMQUIST, SJ
    MULLER, CD
    EUGUI, EM
    TRANSPLANTATION PROCEEDINGS, 1991, 23 (02) : 10 - 14
  • [33] Cytotoxic and genotoxic effects of high concentrations of the immunosuppressive drugs cyclosporine and tacrolimus in MRC-5 cells
    Ciliao, H. L.
    Ribeiro, D. L.
    Camargo-Godoy, R. B. O.
    Specian, A. F. L.
    Serpeloni, J. M.
    Colus, I. M. S.
    EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2015, 67 (02) : 179 - 187
  • [34] Mycophenolic acid interaction with cyclosporine and tacrolimus in vitro and in vivo - Evaluation of additive effects on rat blood lymphocyte function
    Barten, MJ
    Shipkova, M
    Bartsch, P
    Dhein, S
    Streit, F
    Tarnok, A
    Armstrong, VW
    Mohr, FW
    Oellerich, M
    Gummert, JE
    THERAPEUTIC DRUG MONITORING, 2005, 27 (02) : 123 - 131
  • [35] Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine and tenofovir
    Hossain, MM
    Coull, JJ
    Drusano, GL
    Margolis, DM
    ANTIVIRAL RESEARCH, 2002, 55 (01) : 41 - 52
  • [36] LYMPHOCYTE-SELECTIVE CYTOSTATIC AND IMMUNOSUPPRESSIVE EFFECTS OF MYCOPHENOLIC-ACID INVITRO - ROLE OF DEOXYGUANOSINE NUCLEOTIDE DEPLETION
    EUGUI, EM
    ALMQUIST, SJ
    MULLER, CD
    ALLISON, AC
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1991, 33 (02) : 161 - 173
  • [37] Short-term treatment with mycophenolic acid and tacrolimus is tolerogenic for INS-1 cell clone transplantation and the deleterious effects of the drugs are limited:: in vivo and in vitro studies
    Asfari, M
    Berta, S
    Coffy, S
    Kergoat, M
    Charon, C
    Audet, A
    JOURNAL OF ENDOCRINOLOGY, 2005, 186 (01) : 213 - 220
  • [38] THE SYNERGISTIC EFFECTS OF COMBINATION TREATMENTS OF HYPERTHERMIA AND ANTICANCER DRUGS ON CELL SURVIVALS INVITRO
    FURUKAWA, M
    YOSHIKAWA, S
    YAMAGATA, K
    KANO, E
    JOURNAL OF RADIATION RESEARCH, 1984, 25 (01) : 67 - 67
  • [39] Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages
    Ialongo, Davide
    Tudino, Valeria
    Arpacioglu, Merve
    Messore, Antonella
    Patacchini, Elisa
    Costi, Roberta
    Di Santo, Roberto
    Madia, Valentina Noemi
    PHARMACEUTICALS, 2023, 16 (05)
  • [40] Unexpected augmentation of mycophenolic acid pharmacokinetics in renal transplant patients receiving tacrolimus and mycophenolate mofetil in combination therapy, and analogous in vitro findings
    Zucker, K
    Rosen, A
    Tsaroucha, A
    deFaria, L
    Roth, D
    Ciancio, G
    Esquenazi, V
    Burke, G
    Tzakis, A
    Miller, J
    TRANSPLANT IMMUNOLOGY, 1997, 5 (03) : 225 - 232
12345