Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid

被引：48
|
作者：
Vieregge, B [1 ]
Resch, K [1 ]
Kaever, V [1 ]
机构：
[1] Med Hsch Hannover, Inst Klin Mol Pharmakol, D-30623 Hannover, Germany
来源：
PLANTA MEDICA | 1999年 / 65卷 / 01期
关键词：
D O I：
10.1055/s-2006-960446
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The alkaloid sinomenine extracted from the medicinal plant Sinomenium acutum is used in China for the treatment of various rheumatic diseases, It has immunomodulatory properties in a cardiac allograft transplantation model. Its antiproliferative effect on human mononuclear cells in combination with different immunosuppressive drugs was further analysed in vitro. Sinomenine dose-dependently attenuated thymidine incorporation, interleukin-2 synthesis, and cell cycle progression of activated T-lymphocytes. Cell proliferation was synergistically decreased by addition of sinomenine together with suboptimal concentrations of the established immunosuppressive drugs tacrolimus or mycophenolic acid, respectively.
引用
收藏
页码：80 / 82
页数：3
相关论文
共 50 条
  • [21] Synergistic Effects of Digitoxin Analogues in Combination with Chemotherapeutic Drugs
    Hinds, John William
    McKenna, Sean
    FASEB JOURNAL, 2013, 27
  • [22] Validity of trough versus AUC monitoring of mycophenolic acid in transplant recipients depending on the combination with cyclosporin or tacrolimus
    Svinarov, D.
    Genova, M.
    CLINICA CHIMICA ACTA, 2019, 493 : S700 - S700
  • [23] Synergistic immunosuppressive effects of rosmarinic acid and rapamycin in vitro and in vivo
    Yun, SY
    Hur, YG
    Kang, MA
    Lee, J
    Ahn, C
    Won, J
    TRANSPLANTATION, 2003, 75 (10) : 1758 - 1760
  • [24] INVITRO IMMUNOSUPPRESSIVE EFFECTS OF FK506 IN COMBINATION WITH OTHER DRUGS
    ZEEVI, A
    DUQUESNOY, R
    EIRAS, G
    RABINOWICH, H
    TODO, S
    MAKOWKA, L
    STARZL, TE
    TRANSPLANTATION PROCEEDINGS, 1988, 20 (01) : 220 - 222
  • [25] IN VITRO STUDIES OF THE IMMUNOMODULATORY EFFECTS OF STATINS ALONE AND IN COMBINATION WITH IMMUNOSUPPRESSIVE DRUGS
    Guillen, D.
    Millan, O.
    Brunet, M.
    EUROPEAN JOURNAL OF INFLAMMATION, 2011, 9 (02) : 117 - 124
  • [26] Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: Importance of mycophenolic acid therapeutic drug monitoring
    Meiser, BM
    Pfeiffer, M
    Schmidt, D
    Reichenspurner, H
    Ueberfuhr, P
    Paulus, D
    von Scheidt, W
    Kreuzer, E
    Seidel, D
    Reichart, B
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 1999, 18 (02): : 143 - 149
  • [27] The efficacy of the combination of tacrolimus and mycophenolate mofetil for prevention of acute myocardial rejection is dependent on routine monitoring of mycophenolic acid trough acid levels
    Meiser, BM
    Pfeiffer, M
    Schmidt, D
    Ueberfuhr, P
    Reichenspurner, H
    Paulus, D
    von Scheidt, W
    Kreuzer, E
    Seidel, D
    Reichart, B
    TRANSPLANTATION PROCEEDINGS, 1999, 31 (1-2) : 84 - 87
  • [28] Synergistic effects of rapamycin and tacrolimus are preferential to its combination with cyclosporin in the development of intimal hyperplasia
    Waller, JR
    Bicknell, GR
    Murphy, GJ
    Nicholson, ML
    BRITISH JOURNAL OF SURGERY, 2002, 89 : 55 - 55
  • [29] Synergistic hepatotoxic effects with a combination of methylglyoxal and palmitic acid
    Walter, T. L.
    Mabley, J. G.
    DIABETOLOGIA, 2014, 57 : S35 - S35
  • [30] Pharmacokinetics of mycophenolic acid (MEPA) and its glucuronide metabolite (MPAG) in liver Tx in combination therapy with tacrolimus, with or without steroids
    Regazzi, M
    Molinaro, M
    Montagna, M
    Bartoli, A
    Cusato, M
    Arienti, B
    De Simone, A
    Reggiani, P
    THERAPEUTIC DRUG MONITORING, 2003, 25 (04) : 535 - 535
12345