Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid

被引：48
|
作者：
Vieregge, B [1 ]
Resch, K [1 ]
Kaever, V [1 ]
机构：
[1] Med Hsch Hannover, Inst Klin Mol Pharmakol, D-30623 Hannover, Germany
来源：
PLANTA MEDICA | 1999年 / 65卷 / 01期
关键词：
D O I：
10.1055/s-2006-960446
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The alkaloid sinomenine extracted from the medicinal plant Sinomenium acutum is used in China for the treatment of various rheumatic diseases, It has immunomodulatory properties in a cardiac allograft transplantation model. Its antiproliferative effect on human mononuclear cells in combination with different immunosuppressive drugs was further analysed in vitro. Sinomenine dose-dependently attenuated thymidine incorporation, interleukin-2 synthesis, and cell cycle progression of activated T-lymphocytes. Cell proliferation was synergistically decreased by addition of sinomenine together with suboptimal concentrations of the established immunosuppressive drugs tacrolimus or mycophenolic acid, respectively.
引用
收藏
页码：80 / 82
页数：3
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