Solubility of a poorly soluble immunosuppressant in different pure solvents: Measurement, correlation, thermodynamics and molecular interactions

被引：33
|
作者：
Abul Kalam, Mohd [1 ]
Khan, Abdul Arif [1 ]
Alshamsan, Aws [1 ]
Haque, Anzarul [2 ]
Shakeel, Faiyaz [3 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut, Nanomed Res Unit, POB 2457, Riyadh 11451, Saudi Arabia
[2] Prince Sattam bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj, Saudi Arabia
[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, POB 2457, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF MOLECULAR LIQUIDS | 2018年 / 249卷
关键词：
Activity coefficient; Dissolution thermodynamics; lmmunosuppressant; Molecular interaction; Pure solvent; Solubility; PLUS WATER MIXTURES; DIFFERENT NEAT SOLVENTS; DIFFERENT MONO SOLVENTS; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; MYCOPHENOLATE-MOFETIL; DIFFERENT TEMPERATURES; 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE; PARAMETERS; CALCIUM;
D O I：
10.1016/j.molliq.2017.11.028
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The objective of this research work was to measure the solubility of mycophenolate mofetil (MPM) in ten different pure solvents at temperatures T = 298.2 K to 318.2 K and pressure p = 0.1 MPa. The solubilities of MPM in mole fraction were obtained maximum in ethyl acetate (9.28 x 10(-2)) and minimum in water (4.16 x 10(-6)) at "T = 318.2 K" and similar trends were also observed at each temperature investigated. Higher solute-solvents molecular interactions were observed in MPM-ethyl acetate and MPM-Transcutol. Apparent thermodynamic analysis indicated an endothermic and entropy-driven dissolution of MPM in each solvent investigated. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：53 / 60
页数：8
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